Salivary Microbiome Diversity in Kuwaiti Adolescents with Varied Body Mass Index—A Pilot Study
Open Access
- 4 June 2021
- journal article
- research article
- Published by MDPI AG in Microorganisms
- Vol. 9 (6), 1222
- https://doi.org/10.3390/microorganisms9061222
Abstract
The potential role of the salivary microbiome in human diseases has increasingly been explored. The salivary microbiome has been characterized in several global populations, except the Arabian Gulf region. Hence, in this pilot study, we profiled the salivary microbiome of Kuwaiti adolescents with varied body mass indexes (BMI). The analyses of core microbiome composition showed Firmicutes, Bacteroidota, Proteobacteria, Patescibacteria, Fusobacteriota, Actinobacteriota, and Campylobacterota as the common phylum found in the Kuwaiti adolescent population. We also illustrated a diverse microbial community among the sampled individuals grouped according to their BMI. Notably, the overweight group was found with a higher number of distinct taxa than other groups. As such, the core microbiome composition was found to be significantly different (p-value < 0.001) across different BMI groups. Overall, this pilot investigation outlined the microbial diversity and suggested that changes in salivary microbiome composition in people with obese or overweight BMI might reflect their susceptibility to oral diseases.Keywords
Funding Information
- Kuwait Foundation for the Advancement of Sciences (RA-HM-2017-025)
This publication has 61 references indexed in Scilit:
- Richness of human gut microbiome correlates with metabolic markersNature, 2013
- phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census DataPLOS ONE, 2013
- Nurture trumps nature in a longitudinal survey of salivary bacterial communities in twins from early adolescence to early adulthoodGenome Research, 2012
- Structure, function and diversity of the healthy human microbiomeNature, 2012
- Deep Sequencing of the Oral Microbiome Reveals Signatures of Periodontal DiseasePLOS ONE, 2012
- The clinical importance of emerging Campylobacter speciesNature Reviews Gastroenterology & Hepatology, 2011
- The Human Oral MicrobiomeJournal of Bacteriology, 2010
- Global diversity in the human salivary microbiomeGenome Research, 2009
- A core gut microbiome in obese and lean twinsNature, 2008
- Metabolic Endotoxemia Initiates Obesity and Insulin ResistanceDiabetes, 2007