Physical and Oxidative Stability of Uncoated and Chitosan-Coated Liposomes Containing Grape Seed Extract
Open Access
- 20 August 2013
- journal article
- research article
- Published by MDPI AG in Pharmaceutics
- Vol. 5 (3), 421-433
- https://doi.org/10.3390/pharmaceutics5030421
Abstract
Polyphenol-rich grape seed extract (0.1 w/w%) was incorporated in liposomes (1 w/w% soy lecithin) by high pressure homogenization (22,500 psi) and coated with chitosan (0.1 w/w%). Primary liposomes and chitosan-coated secondary liposomes containing grape seed extract showed good physical stability during 98 days of storage. Most of the polyphenols were incorporated in the shell of the liposomes (85.4%), whereas only 7.6% of the polyphenols of grape seed extract were located in the interior of the liposomes. Coating with chitosan did not change the polyphenol content in the liposomes (86.6%). The uncoated liposomes without grape seed extract were highly prone to lipid oxidation. The cationic chitosan coating, however, improved the oxidative stability to some extent, due to its ability to repel pro-oxidant metals. Encapsulated grape seed extract showed high antioxidant activity in both primary and secondary liposomes, which may be attributed to its polyphenol content. In conclusion, the best chemical stability of liposomes can be achieved using a combination of grape seed extract and chitosan.This publication has 25 references indexed in Scilit:
- Carboxymethylchitosan-coated proliposomes containing coix seed oil: Characterisation, stability and in vitro release evaluationFood Chemistry, 2011
- Encapsulation of polyphenolic grape seed extract in polymer-coated liposomesFood & Function, 2011
- Fatty acid composition, oxidative stability, antioxidant and antiproliferative properties of selected cold-pressed grape seed oils and floursFood Chemistry, 2011
- Evaluation of chitosan gel containing liposome-loaded epidermal growth factor on burn wound healingInternational Wound Journal, 2011
- Recent advances of chitosan nanoparticles as drug carriersInternational Journal of Nanomedicine, 2011
- Structured emulsion-based delivery systems: Controlling the digestion and release of lipophilic food componentsAdvances in Colloid and Interface Science, 2010
- Functional Biopolymer Particles: Design, Fabrication, and ApplicationsComprehensive Reviews in Food Science and Food Safety, 2010
- Residues of grape (Vitis vinifera L.) seed oil production as a valuable source of phenolic antioxidantsFood Chemistry, 2009
- Nanoliposomes and Their Applications in Food NanotechnologyJournal of Liposome Research, 2008
- Recent trends in the lipid‐based nanoencapsulation of antioxidants and their role in foodsJournal of the Science of Food and Agriculture, 2006