Bee Venom Acupuncture Attenuates Oxaliplatin-Induced Neuropathic Pain by Modulating Action Potential Threshold in A-Fiber Dorsal Root Ganglia Neurons
Open Access
- 24 November 2020
- Vol. 12 (12), 737
- https://doi.org/10.3390/toxins12120737
Abstract
Oxaliplatin is a third-generation platinum-based chemotherapeutic drug widely used in colorectal cancer treatment. Although potent against this tumor, it can induce cold and mechanical allodynia even after a single injection. The currently used drugs to attenuate this allodynia can also cause unwanted effects, which limit their use. Bee venom acupuncture (BVA) is widely used in Korean medicine to treat pain. Although the effect of BVA on oxaliplatin-induced neuropathic pain has been addressed in many studies, its action on dorsal root ganglia (DRG) neurons has never been investigated. A single oxaliplatin injection (6 mg/kg, intraperitoneally) induced cold and mechanical allodynia, and BVA (0.1 and 1 mg/kg, subcutaneous, ST36) dose-dependently decreased allodynia in rats. On acutely dissociated lumbar 4–6 DRG neurons, 10 min application of oxaliplatin (100 μM) shifted the voltage-dependence of sodium conductance toward negative membrane potentials in A- but not C-fibers. The resting membrane potential remained unchanged, but the action potential threshold decreased significantly compared to that of the control (p < 0.05). However, 0.1 μg/mL of BVA administration increased the lowered action potential threshold. In conclusion, these results suggest that BVA may attenuate oxaliplatin-induced neuropathic pain by altering the action potential threshold in A-fiber DRG neurons.Keywords
This publication has 52 references indexed in Scilit:
- Effect of Bee Venom Acupuncture on Oxaliplatin-Induced Cold Allodynia in RatsEvidence-Based Complementary and Alternative Medicine, 2013
- Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na V 1.6-resurgent and persistent currentProceedings of the National Academy of Sciences of the United States of America, 2012
- The effects of oxaliplatin, an anticancer drug, on potassium channels of the peripheral myelinated nerve fibres of the adult ratNeuroToxicology, 2008
- The roles of sodium channels in nociception: Implications for mechanisms of painPain, 2007
- Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compoundsPharmacology & Therapeutics, 2007
- The role of sodium channels in neuropathic painSeminars in Cell & Developmental Biology, 2006
- Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injuryBrain, 2005
- Sex differences in pain perception and anxiety. A psychophysical study with topical capsaicinPain, 2004
- Clinical aspects and molecular basis of oxaliplatin neurotoxicity: Current management and development of preventive measuresSeminars in Oncology, 2002
- Prophylaxe der Oxaliplatin-induzierten Neuropathie mit Carbamazepin¹ - Eine Pilotstudie -Deutsche Medizinische Wochenschrift (1946), 2002