Efficacy and Freedom: Patient Experiences with the Transition from Daily Oral to Long-Acting Injectable Antiretroviral Therapy to Treat HIV in the Context of Phase 3 Trials
- 14 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in AIDS and Behavior
- Vol. 24 (12), 3473-3481
- https://doi.org/10.1007/s10461-020-02918-x
Abstract
Long-acting injectable antiretroviral therapy (LA ART) may be an alternative for people living with HIV (PLHIV) with adherence challenges or who prefer not to take pills. Using in-depth interviews, this study sought to understand the experiences of PLHIV (n = 53) participating in Phase 3 LA ART trials in the United States and Spain. The most salient consideration when contemplating LA ART was its clinical efficacy; many participants reported wanting to ensure that it worked as well as daily oral ART, including with less frequent dosing (every 8 versus 4 weeks). While injection side effects were often reported, most participants felt that regimen benefits outweighed such drawbacks. Participants described the main benefit of LA ART as the “freedom” it afforded both logistically and psychosocially, including through reduced HIV stigma. Findings highlight the importance of patient-provider communication related to weighing potential benefits and side effects and the continued need to address HIV stigma.Keywords
Funding Information
- ViiV Healthcare (No award Number)
This publication has 37 references indexed in Scilit:
- High Coverage of ART Associated with Decline in Risk of HIV Acquisition in Rural KwaZulu-Natal, South AfricaScience, 2013
- HIV treatment as prevention and HPTN 052Current Opinion in HIV and AIDS, 2012
- Adherence to HIV Treatment and Care Among Previously Homeless Jail DetaineesAIDS and Behavior, 2011
- Dose-response Effect of Incarceration Events on Nonadherence to HIV Antiretroviral Therapy Among Injection Drug UsersThe Journal of Infectious Diseases, 2011
- Homelessness and Adherence to Antiretroviral Therapy among a Cohort of HIV-Infected Injection Drug UsersJournal of Urban Health, 2011
- The Spectrum of Engagement in HIV Care and its Relevance to Test-and-Treat Strategies for Prevention of HIV InfectionClinical Infectious Diseases, 2011
- Association of ongoing drug and alcohol use with non-adherence to antiretroviral therapy and higher risk of AIDS and death: results from ACTG 362AIDS Care, 2011
- Structural barriers to ART adherence in Southern Africa: Challenges and potential ways forwardGlobal Public Health, 2011
- Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based studyThe Lancet, 2010
- Barriers to acceptance and adherence of antiretroviral therapy in urban Zambian women: a qualitative studyAIDS Care, 2008