Validation of the QLQ-EN24 instrument for the assessment of health-related quality of life for women with endometrial cancer in México
- 13 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Archiv für Gynäkologie
- Vol. 304 (3), 773-782
- https://doi.org/10.1007/s00404-021-05990-3
Abstract
Purpose The impact of disease activity or treatments on health-related quality of life (HRQL) is crucial in Oncology, but adequate instruments for this assessment are scarce. Our aim is to validate the Mexican-Spanish version of the QLQ-EN24 questionnaire to evaluate HRQL in women with endometrial cancer (EC). Methods This is a prospective study of Mexican women with EC, attending a single cancer centre, who responded the QLQ-C30 and QLQ-EN24 instruments; usual psychometric analysis were performed as well as the association of HRQL scales and relevant clinical data. Correlation analysis was performed with the Spearman’s method, reliability analysis with the Cronbach’s alpha, known-group comparisons with the Kruskal–Wallis test, and survival analysis with the Kaplan–Meier method and Log-rank test. Results One hundred and eighty-nine women with EC were assessed. Most functional scales reported high values, and most symptom scales, low. Questionnaire compliance rates were high and internal consistency tests demonstrated adequate convergent and divergent validity. Cronbach’s α coefficients of the five multi-item scales the QLQ-EN24 instruments were from 0.659 to 0.887. Scales of the QLQ-C30 and QLQ-EN24 instruments distinguished among clinically distinct groups of patients, particularly based on serum albumin levels. The Urological symptoms, Gastrointestinal symptoms, Body image, Pelvic pain and Taste change scales were significantly associated with OS. Conclusion The Mexican-Spanish version of the QLQ-EN24 questionnaire is reliable and valid for the assessment of HRQL in patients with EC and can be broadly used in multi-national clinical trials. However, conclusions derived from scales evaluating sexual function should be handled carefully.Keywords
This publication has 23 references indexed in Scilit:
- A global analysis of multitrial data investigating quality of life and symptoms as prognostic factors for survival in different tumor sitesCancer, 2013
- Quality of life in patients with endometrial cancer treated with or without systematic lymphadenectomyEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2013
- The relationship of body mass index with quality of life among endometrial cancer survivors: A study from the population-based PROFILES registryGynecologic Oncology, 2013
- Health related quality of life and symptoms after pelvic lymphadenectomy or radiotherapy vs. no adjuvant regional treatment in early-stage endometrial carcinoma: A large population-based studyGynecologic Oncology, 2012
- Revised FIGO Staging System for Endometrial CancerClinical Obstetrics and Gynecology, 2011
- Psychometric validation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Endometrial Cancer Module (EORTC QLQ-EN24)European Journal of Cancer, 2011
- Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysisThe Lancet, 2009
- Validation of the Mexican Spanish Version of the EORTC C30 and STO22 Questionnaires for the Evaluation of Health-Related Quality of Life in Patients with Gastric CancerAnnals of Surgical Oncology, 2009
- Treatment effects, disease recurrence, and survival in obese women with early endometrial carcinomaCancer, 2006
- The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in OncologyJNCI Journal of the National Cancer Institute, 1993