The Great Oxidation Event expanded the genetic repertoire of arsenic metabolism and cycling
Open Access
- 29 April 2020
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 117 (19), 10414-10421
- https://doi.org/10.1073/pnas.2001063117
Abstract
The rise of oxygen on the early Earth about 2.4 billion years ago reorganized the redox cycle of harmful metal(loids), including that of arsenic, which doubtlessly imposed substantial barriers to the physiology and diversification of life. Evaluating the adaptive biological responses to these environmental challenges is inherently difficult because of the paucity of fossil records. Here we applied molecular clock analyses to 13 gene families participating in principal pathways of arsenic resistance and cycling, to explore the nature of early arsenic biogeocycles and decipher feedbacks associated with planetary oxygenation. Our results reveal the advent of nascent arsenic resistance systems under the anoxic environment predating the Great Oxidation Event (GOE), with the primary function of detoxifying reduced arsenic compounds that were abundant in Archean environments. To cope with the increased toxicity of oxidized arsenic species that occurred as oxygen built up in Earth’s atmosphere, we found that parts of preexisting detoxification systems for trivalent arsenicals were merged with newly emerged pathways that originated via convergent evolution. Further expansion of arsenic resistance systems was made feasible by incorporation of oxygen-dependent enzymatic pathways into the detoxification network. These genetic innovations, together with adaptive responses to other redox-sensitive metals, provided organisms with novel mechanisms for adaption to changes in global biogeocycles that emerged as a consequence of the GOE.This publication has 64 references indexed in Scilit:
- SINA: Accurate high-throughput multiple sequence alignment of ribosomal RNA genesBioinformatics, 2012
- ProtTest 3: fast selection of best-fit models of protein evolutionBioinformatics, 2011
- History of biological metal utilization inferred through phylogenomic analysis of protein structuresProceedings of the National Academy of Sciences of the United States of America, 2010
- PhyloBayes 3: a Bayesian software package for phylogenetic reconstruction and molecular datingBioinformatics, 2009
- trimAl: a tool for automated alignment trimming in large-scale phylogenetic analysesBioinformatics, 2009
- Photoferrotrophs thrive in an Archean Ocean analogueProceedings of the National Academy of Sciences of the United States of America, 2008
- Convergent Evolution of a New Arsenic Binding Site in the ArsR/SmtB Family of MetalloregulatorsOnline Journal of Public Health Informatics, 2007
- Modern proteomes contain putative imprints of ancient shifts in trace metal geochemistryProceedings of the National Academy of Sciences of the United States of America, 2006
- Multiple Sequence Alignment Using ClustalW and ClustalXCurrent Protocols in Bioinformatics, 2002
- T-coffee: a novel method for fast and accurate multiple sequence alignmentJournal of Molecular Biology, 2000