Integrated targeted serum metabolomic profile and its association with gender, age, disease severity, and pattern identification in acne
Open Access
- 17 January 2020
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 15 (1), e0228074
- https://doi.org/10.1371/journal.pone.0228074
Abstract
Westernized diet and nutritional metabolism are important in acne pathogenesis, especially in adult patients. However, clinical and basic data are lacking. Pattern identification (PI) is a tool that results in a diagnostic conclusion based on a cluster of concurrent symptoms and signs in traditional medicine. Acne can be classified by PI. However, whether the metabolomic profile differs according to the PI of acne is unknown. Metabolomic data would help clarify the pathogenesis of acne. We conducted a cross-sectional study involving 40 healthy controls and 60 subjects with acne. We evaluated androgens, serum lipids, essential amino acids, nonessential amino acids, other amino acids, and pro-inflammatory cytokines of all subjects and compared the metabolomic profiles between acne subjects and healthy controls, and in subgroups according to gender, age, severity, and PI. Dehydroepiandrosterone sulfate and serum fatty acids were significantly higher in female subjects, adolescents, and those with disharmony of the thoroughfare and conception vessels. The total essential and nonessential amino acids were significantly lower in the overall, female, adult, severe, and phlegm-stasis group. The latter group exhibited elevated serum levels of interleukin-1β and -6. This is the first study to investigate serum lipids, amino acids, and cytokines in subjects with acne. We analyzed the differences between metabolomic profiles to determine the diagnostic value of PI. Prospective studies with more patients are needed to confirm the characteristics of each PI and lipidomic data will enrich knowledge concerning lipid mechanism.Funding Information
- the Ministry of Health & Welfare through the Korea Health Industry Development Institute (HI16C0801)
- a National Research Foundation of Korea Grant, funded by the Korean Government (NRF-2017R1A1A1A05001218)
This publication has 52 references indexed in Scilit:
- Acne: The Role of Medical Nutrition TherapyJournal of the Academy of Nutrition and Dietetics, 2013
- Epigallocatechin-3-Gallate Suppresses IGF-I-Induced Lipogenesis and Cytokine Expression in SZ95 SebocytesJournal of Investigative Dermatology, 2012
- Novel, Objective, Multivariate Biomarkers Composed of Plasma Amino Acid Profiles for the Diagnosis and Assessment of Inflammatory Bowel DiseasePLOS ONE, 2012
- Variation of Biophysical Parameters of the Skin with Age, Gender, and Body RegionThe Scientific World Journal, 2012
- Dietary intervention in acneDermato-Endocrinology, 2012
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitroExperimental Dermatology, 2011
- Over-stimulation of insulin/IGF-1 signaling by western diet may promote diseases of civilization: lessons learnt from laron syndromeNutrition & Metabolism, 2011
- A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin ResistanceCell Metabolism, 2009
- The prevalence of acne in adults 20 years and olderJournal of the American Academy of Dermatology, 2008
- Predictors of severity of acne vulgaris in young adolescent girls: Results of a five-year longitudinal studyThe Journal of Pediatrics, 1997