Biomedical Application of Functional Materials in Organ-on-a-Chip
Open Access
- 22 July 2020
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Bioengineering and Biotechnology
- Vol. 8, 823
- https://doi.org/10.3389/fbioe.2020.00823
Abstract
The organ-on-a-chip (OOC) technology has been utilized in a lot of biomedical fields such as fundamental physiological and pharmacological researches. Various materials have been introduced in OOC and can be broadly classified into inorganic, organic, and hybrid materials. Although PDMS continues to be the preferred material for laboratory research, materials for OOC are constantly evolving and progressing, and have promoted the development of OOC. This mini review provides a summary of the various type of materials for OOC systems, focusing on the progress of materials and related fabrication technologies within the last 5 years. The advantages and drawbacks of these materials in particular applications are discussed. In addition, future perspectives and challenges are also discussed.Keywords
This publication has 120 references indexed in Scilit:
- Circumferential alignment of vascular smooth muscle cells in a circular microfluidic channelBiomaterials, 2014
- Clay: New Opportunities for Tissue Regeneration and Biomaterial DesignAdvanced Materials, 2013
- Hydrogel-coated microfluidic channels for cardiomyocyte cultureLab on a Chip, 2013
- Designing Cell-Compatible Hydrogels for Biomedical ApplicationsScience, 2012
- In vitro microvessels for the study of angiogenesis and thrombosisProceedings of the National Academy of Sciences of the United States of America, 2012
- Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flowLab on a Chip, 2012
- Rapid prototyping polymers for microfluidic devices and high pressure injectionsLab on a Chip, 2011
- Reconstituting Organ-Level Lung Functions on a ChipScience, 2010
- Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicityBiotechnology & Bioengineering, 2009
- The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen SensorsBiotechnology Progress, 2008