Performance of HDTMA-Br-Modified Indonesian Zeolite as a Drug Carrier Candidate for Diclofenac Sodium
Open Access
- 28 March 2021
- journal article
- Published by Institute of Research and Community Services Diponegoro University (LPPM UNDIP) in Jurnal Kimia Sains dan Aplikasi
- Vol. 24 (3), 91-100
- https://doi.org/10.14710/jksa.24.3.91-100
Abstract
Diclofenac sodium is a non-steroidal anti-inflammatory drug with a relatively short release time. This short release time promotes a more frequent drug consumption and could lead to side effects in the stomach, e.g., gastrointestinal disorders, gastrointestinal bleeding, and gastric ulcers. A drug delivery system with a slow-release activity is one of the promising technologies to control the drug amount released to the stomach. A surfactant-modified natural zeolite as a carrier for diclofenac sodium has been used in this study. This study focused on the preparation, characterization, and slow-release performance of HDTMA-modified natural zeolite as a carrier for diclofenac sodium. The zeolite underwent chemical and physical activation, as well as milling prior to use. It was proven that the zeolite used was dominated by mordenite and clinoptilolite with high stability properties towards acid treatments, as indicated by the XRD patterns. A modification of the zeolite surface using HDTMABr was also successfully performed, indicated by the appearance of peaks at wavenumbers of 2923.05 cm-1 and 2853.39 cm-1 (symmetrical and asymmetrical CH2 strains of HDTMA molecules, respectively) in the FTIR spectra. The synthesized HDTMA-modified natural zeolite also showed an excellent surface property such as surface area, pore-volume, and size, as indicated by the BET-BJH isotherms on the nitrogen adsorption. The slow-release performance of the zeolite-based drug delivery system was studied by investigating the adsorption-desorption behavior of HDTMA-modified zeolite towards diclofenac sodium. The HDTMA-modified zeolite adsorbed the diclofenac sodium of 54.01% at a pH of 7.5, the contact time of 60 min, and the initial concentration of 100 ppm. The adsorbed diclofenac sodium of 73.95% could be released from the HDTMA-modified adsorbent for 8 h, mimicking the time length of drug metabolism in the human body.Keywords
Funding Information
- Universitas Negeri Semarang
This publication has 24 references indexed in Scilit:
- The Scherrer equation versus the 'Debye-Scherrer equation'Nature Nanotechnology, 2011
- Sorption of HDTMA cations on Croatian natural mordenite tuffJournal of Hazardous Materials, 2011
- Optimized experimental design for natural clinoptilolite zeolite ball milling to produce nano powdersPowder Technology, 2010
- Adsolubilization of drugs onto natural clinoptilolite modified by adsorption of cationic surfactantsColloids and Surfaces B: Biointerfaces, 2010
- Zn2+-exchanged clinoptilolite-rich rock as active carrier for antibiotics in anti-acne topical therapy: In-vitro characterization and preliminary formulation studiesApplied Clay Science, 2007
- Pore classification in the characterization of porous materials: A perspectiveOpen Chemistry, 2007
- Metal–Organic Frameworks as Efficient Materials for Drug DeliveryAngewandte Chemie, 2006
- Structural and physicochemical properties of natural zeolites: clinoptilolite and mordeniteMicroporous and Mesoporous Materials, 2006
- Clinoptilolite–surfactant composites as drug support: A new potential applicationMicroporous and Mesoporous Materials, 2005
- Long-Term Chemical and Biological Stability of Surfactant-Modified ZeoliteEnvironmental Science & Technology, 1998