Experimental study on novel biodegradable Zn – Fe – Si alloys
- 6 May 2022
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Vol. 110 (10), 2266-2275
- https://doi.org/10.1002/jbm.b.35075
Abstract
Bioabsorbable metals are increasingly attracting attention for their potential use as materials for degradable implant devices. Zinc (Zn) alloys have shown great promises due to their good biocompatibility and favorable degradation rate. However, it has been difficult to maintain an appropriate balance among strength, ductility, biocompatibility, and corrosion rate for Zn alloys historically. In this study, the microstructure, chemical composition, mechanical properties, biocompatibility, and corrosion rate of a new ternary zinc-iron-silicon (Zn-Fe-Si) alloy system was studied as a novel material for potential biodegradable implant applications. The results demonstrated that the in situ formed Fe-Si intermetallic phases enhanced the mechanical strength of the material while maintaining a favorable ductility. With Fe-Si reinforcements, the microhardness of the Zn alloys was enhanced by up to 43%. The tensile strength was increased by up to 76% while elongation to failure remained above 30%. Indirect cytotoxicity testing showed the Zn-Fe-Si system had good biocompatibility. Immersion testing revealed the corrosion rate of Zn-Fe-Si system was not statistically different from pure Zn. To understand the underlying phase formation mechanism, the reaction process in this ternary system during the processing was also studied via phase evolution and Gibbs free energy analysis. The results suggest the Zn-Fe-Si ternary system is a promising new material for bioabsorbable metallic medical devices.Keywords
Funding Information
- National Heart, Lung, and Blood Institute (R01HL143465)
This publication has 49 references indexed in Scilit:
- Toxic Effect of Silica Nanoparticles on Endothelial Cells through DNA Damage Response via Chk1-Dependent G2/M CheckpointPLOS ONE, 2013
- Zinc Exhibits Ideal Physiological Corrosion Behavior for Bioabsorbable StentsAdvanced Materials, 2013
- Biodegradable Metals for Cardiovascular Stent Application: Interests and New OpportunitiesInternational Journal of Molecular Sciences, 2011
- The Evolving Role of Inflammatory Biomarkers in Risk Assessment After Stent ImplantationJournal of the American College of Cardiology, 2010
- Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cellsInternational Journal of Nanomedicine, 2010
- Contribution of Orowan strengthening effect in particulate-reinforced metal matrix nanocompositesMaterials Science and Engineering: A, 2008
- Stable and metastable iron silicide phases on Si(100)Surface Science, 2005
- Impact of strut thickness on late luminal loss after coronary artery stent placementThe American Journal of Cardiology, 2004
- 450 °C Isothermal Section of the Fe-Zn-Si Ternary Phase DiagramCanadian Metallurgical Quarterly, 2001
- Laser surface modification of UNS S31603 stainless steel. Part I: microstructures and corrosion characteristicsMaterials Science and Engineering: A, 2000