A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles
- 18 November 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 12 (570)
- https://doi.org/10.1126/scitranslmed.aay5445
Abstract
The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in Cutibacterium acnes (formerly Propionibacterium acnes), a human skin commensal bacterium that is widely distributed across individuals and skin sites. Experimental characterization of this biosynthetic gene cluster resulted in identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles revealed that cutimycin contributed to the ecology of the skin hair follicle microbiota and helped to reduce colonization of skin hair follicles by Staphylococcus species.Funding Information
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases (R01 AI101018)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP1 DK113598)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK110174)
- National Center for Complementary and Alternative Medicine (U41 AT008718)
- Burroughs Wellcome Fund
- Natural Sciences and Engineering Research Council of Canada (RGPIN-2016-03962)
This publication has 41 references indexed in Scilit:
- Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with AcneJournal of Investigative Dermatology, 2013
- The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffoldsProceedings of the National Academy of Sciences of the United States of America, 2013
- Fermentation of Propionibacterium acnes, a Commensal Bacterium in the Human Skin Microbiome, as Skin Probiotics against Methicillin-Resistant Staphylococcus aureusPLOS ONE, 2013
- Structure, function and diversity of the healthy human microbiomeNature, 2012
- Comparative In Vitro Activities of LFF571 against Clostridium difficile and 630 Other Intestinal Strains of Aerobic and Anaerobic BacteriaAntimicrobial Agents and Chemotherapy, 2012
- A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing dataBioinformatics, 2011
- Comparative Genomics and Transcriptomics of Propionibacterium acnesPLOS ONE, 2011
- Staphylococcuscolonization of the skin and antimicrobial peptidesExpert Review of Dermatology, 2010
- Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillinProceedings of the National Academy of Sciences of the United States of America, 2009
- Skin microbiota: a source of disease or defence?British Journal of Dermatology, 2008