Systematic Review and Meta-Analysis of the Clinical Utility of the ADOS-2 and the ADI-R in Diagnosing Autism Spectrum Disorders in Children
- 21 January 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Autism and Developmental Disorders
- Vol. 51 (11), 4101-4114
- https://doi.org/10.1007/s10803-020-04839-z
Abstract
The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) and the Autism Diagnostic Interview, Revised (ADI-R) have high accuracy as diagnostic instruments in research settings, while evidence of accuracy in clinical settings is less robust. This meta-analysis focused on efficacy of these measures in research versus clinical settings. Articles (n = 22) were analyzed using a hierarchical summary receiver operating characteristics (HSROC) model. ADOS-2 performance was stronger than the ADI-R. ADOS-2 sensitivity and specificity ranged from .89-.92 and .81-.85, respectively. ADOS-2 accuracy in research compared with clinical settings was mixed. ADI-R sensitivity and specificity were .75 and .82, respectively, with higher specificity in research samples (Research = .85, Clinical = .72). A small number of clinical studies were identified, indicating ongoing need for investigation outside research settings.Keywords
Funding Information
- Health Resources and Services Administration (HRSA) Maternal and Child Health Bureau (MCH) Leadership Education in Neurodevelopmental and Related Disabilities
- UAB Civitan International Science Center and Foundation for Children with Intellectual and Developmental Disabilities McNulty Scientist Award
- UAB Civitan Sparks Clinics
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