Allergic reactions are of increasing concern to practitioners in health-related fields. In modern orthodontic practice, adverse patient reactions to orthodontic materials are of both an irritant and a allergic in nature. Allergy in patients undergoing orthodontic treatment can be seen due to several reasons and these include nickel allergy, allergy to the acrylic resins that are used during treatment, latex products, etc. Safe and effective practice depends on identifying patients with allergy along with knowledge of materials that can potentially cause them. The Orthodontists should have basic understanding of allergic reactions and should be efficient enough to manage them. The aim of this paper is to review and analyse critically the current available literature in the field of allergy in orthodontics and to provide clinical implications based on scientific evidence on the topic