A review of the phytochemistry, ethnopharmacology and biological activities of Teucrium genus (Germander)
- 5 January 2022
- journal article
- review article
- Published by Taylor & Francis Ltd in Natural Product Research
- Vol. 36 (21), 5647-5664
- https://doi.org/10.1080/14786419.2021.2022669
Abstract
Teucrium L (Lamiaceae) is mainly distributed in the Mediterranean area. A comprehensive survey in the electronic databases (during 2000–2020 years) with keywords of ‘Teucrium’ and ‘Germander’ showed that chemical analyses are available for 27 species, with sesquiterpenoids, iridoids, di and triterpenoids, and phenolic compounds as identified structures. The neo-clerodane diterpenoids as potential chemotaxonomic markers were the main compounds of this genus. As a result, Italy and Turkey have good attempts at phytochemical analysis. The pharmacological activities of different species including antioxidant, cytotoxic activity, antidiabetic, antimicrobial, anti-inflammatory and anti-insect have been summarized. Teucrium polium and Teucrium chamaedrys mainly have been used in digestive problems and diabetes in traditional medicine. Evidence-based clinical trials are needed to confirm the therapeutic properties of this genus. As well to the popularity of Asian and Anatolian species as ingredients in contemporary medicines and products, further research is required in comparison to European species. Graphical AbstractKeywords
This publication has 94 references indexed in Scilit:
- A New Triterpenoid from Teucrium viscidumMolecules, 2013
- Analysis of polyphenols, phytosterols, and bitter principles in Teucrium L. speciesOpen Life Sciences, 2012
- Cytotoxic and anthelmintic potential of crude saponins isolated from Achillea Wilhelmsii C. Koch and Teucrium Stocksianum boissBMC Complementary and Alternative Medicine, 2011
- Further anti-feedantneo-clerodanes fromTeucrium tomentosumNatural Product Research, 2010
- Comparative analysis of medicinal plants used in traditional medicine in Italy and TunisiaJournal of Ethnobiology and Ethnomedicine, 2009
- Hepatitis induced byTeucrium viscidumClinical Toxicology, 2008
- Wild food plants of popular use in SicilyJournal of Ethnobiology and Ethnomedicine, 2007
- Isolation and structure elucidation of three neo-clerodane diterpenes from Teucrium fruticans L. (LABIATAE)Phytochemistry, 2005
- Analgesic and Anti-Inflammatory Activities of Teucrium stocksianumPharmaceutical Biology, 2001
- A rearranged abietane diterpenoid from the root of Teucrium fruticansPhytochemistry, 1990