Dietary Antiplatelets: A New Perspective on the Health Benefits of the Water-Soluble Tomato Concentrate Fruitflow®
Open Access
- 25 June 2021
- Vol. 13 (7), 2184
- https://doi.org/10.3390/nu13072184
Abstract
Our understanding of platelet functionality has undergone a sea change in the last decade. No longer are platelets viewed simply as regulators of haemostasis; they are now acknowledged to be pivotal in coordinating the inflammatory and immune responses. This expanded role for platelets brings new opportunities for controlling a range of health conditions, targeting platelet activation and their interactions with other vascular cells. Antiplatelet drugs may be of wider utility than ever expected but often cause platelet suppression too strong to be used out of clinical settings. Dietary antiplatelets represent a nutritional approach that can be efficacious while safe for general use. In this review, we discuss potential new uses for dietary antiplatelets outside the field of cardiovascular health, with specific reference to the water-soluble tomato extract Fruitflow®. Its uses in different aspects of inflammation and immune function are discussed, highlighting exercise-induced inflammation, mediating the effects of air pollution, and controlling thrombotic aspects of the immune response. Potential future developments in women’s health, erectile dysfunction, and the allergic response indicate how broad the utility of dietary antiplatelets can be.This publication has 82 references indexed in Scilit:
- Protective Mechanisms of Guanosine from Solanum lycopersicum on Agonist-Induced Platelet Activation: Role of sCD40LMolecules, 2013
- Bioassay-Guided Isolation and HPLC Determination of Bioactive Compound That Relate to the Antiplatelet Activity (Adhesion, Secretion, and Aggregation) fromSolanum lycopersicumEvidence-Based Complementary and Alternative Medicine, 2012
- Air pollution‐associated procoagulant changes: the role of circulating microvesiclesJournal of Thrombosis and Haemostasis, 2012
- Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy AdultsMedicine & Science in Sports & Exercise, 2011
- Monomeric C-Reactive Protein Generation on Activated Platelets: The Missing Link Between Inflammation and Atherothrombotic RiskTrends in Cardiovascular Medicine, 2009
- Tomato extract inhibits human platelet aggregationin vitrowithout increasing basal cAMP levelsInternational Journal of Food Sciences and Nutrition, 2004
- Prebiotics affect nutrient digestibility but not faecal ammonia in dogs fed increased dietary protein levelsBritish Journal of Nutrition, 2003
- Effects of strenuous exercise on haemostasisBritish Journal of Sports Medicine, 2003
- Effects of tomato extract on human platelet aggregation in vitroPlatelets, 2001
- SildenafilDrugs, 1999