Association of IgG Glycosylation and Esophageal Precancerosis Beyond Inflammation
- 1 March 2021
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Prevention Research
- Vol. 14 (3), 347-353
- https://doi.org/10.1158/1940-6207.CAPR-20-0489
Abstract
This study aimed to investigate the association of IgG glycosylation and esophageal precancerosis for squamous cell carcinoma and determine its role in inflammation. Primary glycans selected by the least absolute shrinkage and selection operator (LASSO) algorithm were validated using univariate and multivariate logistics models plus restricted cubic spline functions. In total, 24 direct glycans and 27 derived traits were detected, among which four glycans and three derived traits were primarily selected. Then, GP5 (adjusted OR 0.805), GP17 (adjusted OR: 1.305), G12n (adjusted OR 1.271), Gal_1 (adjusted OR 0.776) and Fuc (adjusted OR 0.737) were validated and significantly associated with esophageal precancerosis. In addition, there was a consistent positive association in GP17 and G12n and a negative association in GP5, Gal_1, and Fuc by restricted cubic spline function. Compared with esophageal inflammation, GP17, G12n, and Fuc were still independently associated with precancerosis. In brief, the IgG glycosylation profile was independently associated with esophageal precancerosis beyond inflammation, which could be an early biomarker for esophageal cancer. Prevention Relevance: IgG glycosylation profile is associated with esophageal precancerosis and specific IgG glycans involves in the early stage of esophageal cancer, which is independent of inflammation.Other Versions
Funding Information
- National Key R&D Program of China (2016YFC1302804)
This publication has 33 references indexed in Scilit:
- Glycans and CancerPublished by Elsevier BV ,2015
- Fc Glycan-Modulated Immunoglobulin G Effector FunctionsJournal of Clinical Immunology, 2014
- Alternative glycosylation modulates function of IgG and other proteins — Implications on evolution and diseaseBiochimica et Biophysica Acta (BBA) - General Subjects, 2012
- Immunoglobulin G Fc N-glycan profiling in patients with gastric cancer by LC-ESI-MS: relation to tumor progression and survivalGlycoconjugate Journal, 2011
- High Throughput Isolation and Glycosylation Analysis of IgG–Variability and Heritability of the IgG Glycome in Three Isolated Human PopulationsMolecular & Cellular Proteomics, 2011
- The diagnostic value of the measurement of matrix metalloproteinase 9 (MMP-9), squamous cell cancer antigen (SCC) and carcinoembryonic antigen (CEA) in the sera of esophageal cancer patientsClinica Chimica Acta; International Journal of Clinical Chemistry, 2008
- Fcγ receptors as regulators of immune responsesNature Reviews Immunology, 2008
- A High Expression of GDP-Fucose Transporter in Hepatocellular Carcinoma is a Key Factor for Increases in FucosylationGlycobiology, 2007
- Obesity and lifestyle risk factors for gastroesophageal reflux disease, Barrett esophagus and esophageal adenocarcinomaDiseases of the Esophagus, 2006
- The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular CytotoxicityOnline Journal of Public Health Informatics, 2003