Directionality of Genital Human Papillomavirus Infection Transmission Within Heterosexual Couples: A Systematic Review and Meta-analysis
Open Access
- 3 June 2020
- journal article
- review article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 222 (11), 1928-1937
- https://doi.org/10.1093/infdis/jiaa302
Abstract
Background. Limited evidence indicates greater female-to-male (F-M) transmission of genital infection with human papillomavirus (HPV) relative to male-to-female (M-F). We verified the hypothesis of a differential transmission rate in couple-based studies by conducting a systematic review and meta-analysis. Methods. We searched MEDLINE, EMBASE, Scopus, and Cochrane Library databases for studies published until December 2019. We calculated pooled estimates of F-M and M-F transmission rates and their rate differences per 100 person-months, with 95% confidence intervals (CI), using a random-effects model. We counted occurrences of directionality preponderance for each HPV type. Results. We identified 7 eligible studies published between 2008 and 2019, providing data for 752 couples. Pooled estimates for F-M and M-F transmission rates were 3.01 (95% CI, 1.19-7.64; I-2 = 97%) and 1.60 (95% CI, 0.86-2.98; I-2 = 89%), respectively. The overall rate difference was 0.61 (95% CI, -0.27 to 1.49; I-2 = 75%). Three studies provided rates by sex and HPV genotype; 2 favored a preponderance of F-M and 1 favored M-F transmission. Conclusions. There was slight evidence for a differential transmission rate favoring higher F-M than M-F transmission with substantial statistical heterogeneity across studies.Funding Information
- Canadian Institutes of Health Research (FDN-143347)
This publication has 28 references indexed in Scilit:
- The impact of human immunodeficiency virus on human papillomavirus transmission in heterosexually active couplesJournal of Infection, 2013
- Epithelial Cell Responses to Infection with Human PapillomavirusClinical Microbiology Reviews, 2012
- Genital Transmission of Human Papillomavirus in Recently Formed Heterosexual CouplesThe Journal of Infectious Diseases, 2011
- Human Papillomavirus Concordance in Heterosexual CouplesJournal of Adolescent Health, 2010
- Influence of Partner's Infection Status on Prevalent Human Papillomavirus Among Persons With a New Sex PartnerSexually Transmitted Diseases, 2010
- Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA StatementJournal of Clinical Epidemiology, 2009
- Seroprevalence of Human Papillomavirus Types 6, 11, 16, and 18 in the United States: National Health and Nutrition Examination Survey 2003–2004The Journal of Infectious Diseases, 2009
- Natural history and epidemiology of HPV infection and cervical cancerGynecologic Oncology, 2008
- The Human Papillomavirus Infection in Men Study: Human Papillomavirus Prevalence and Type Distribution among Men Residing in Brazil, Mexico, and the United StatesCancer Epidemiology, Biomarkers & Prevention, 2008
- Chapter 6: Epidemiology and transmission dynamics of genital HPV infectionVaccine, 2006