Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17
Open Access
- 4 February 2021
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Nutrition
Abstract
Flavonifractor plautii (FP) has been reported to participate in the metabolism of catechins in the human gut. However, there is limited information on the immune regulatory effects of this bacterium. We confirmed that the administration of green tea increases the abundance of FP in the gut microbiota and investigated the effect of FP in a mouse colitis model. Mice were orally administered FP for 10 consecutive days; colonic inflammation was evaluated daily on the basis of stool consistency, gross rectal bleeding, and body weight. In the dextran sodium sulfate model, FP-exposed animals exhibited lower levels of inflammation and strong inhibition of interleukin (IL)-17 signaling. Moreover, lipoteichoic acid from FP was identified as the active component mediating IL-17 suppression. Thus, oral administration of FP appears to modulate gut inflammation and represents a viable and inexpensive oral microbial therapeutic.Funding Information
- Japan Society for the Promotion of Science
This publication has 59 references indexed in Scilit:
- Streptococcus thermophilusST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 CellsJournal of Biomedicine and Biotechnology, 2011
- Proposal to unify Clostridium orbiscindens Winter et al. 1991 and Eubacterium plautii (Seguin 1928) Hofstad and Aasjord 1982, with description of Flavonifractor plautii gen. nov., comb. nov., and reassignment of Bacteroides capillosus to Pseudoflavonifractor capillosus gen. nov., comb. nov.International Journal of Systematic and Evolutionary Microbiology, 2010
- Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsisProceedings of the National Academy of Sciences of the United States of America, 2009
- Breastfeeding and genetic factors in the etiology of inflammatory bowel disease in childrenWorld Journal of Gastroenterology, 2009
- Is there a link between food and intestinal microbes and the occurrence of Crohn's disease and ulcerative colitis?Journal of Gastroenterology and Hepatology, 2008
- CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn diseaseJCI Insight, 2007
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsNature, 2006
- Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel diseaseGut, 2004
- The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.The Journal of Experimental Medicine, 1994
- Interleukin-10-deficient mice develop chronic enterocolitisCell, 1993