Repair of DNA Breaks by Break-Induced Replication
- 1 April 2021
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biochemistry
- Vol. 90 (1), 165-191
- https://doi.org/10.1146/annurev-biochem-081420-095551
Abstract
Double-strand DNA breaks (DSBs) are the most lethal type of DNA damage, making DSB repair critical for cell survival. However, some DSB repair pathways are mutagenic and promote genome rearrangements, leading to genome destabilization. One such pathway is break-induced replication (BIR), which repairs primarily one-ended DSBs, similar to those formed by collapsed replication forks or telomere erosion. BIR is initiated by the invasion of a broken DNA end into a homologous template, synthesizes new DNA within the context of a migrating bubble, and is associated with conservative inheritance of new genetic material. This mode of synthesis is responsible for a high level of genetic instability associated with BIR. Eukaryotic BIR was initially investigated in yeast, but now it is also actively studied in mammalian systems. Additionally, a significant breakthrough has been made regarding the role of microhomology-mediated BIR in the formation of complex genomic rearrangements that underly various human pathologies. Expected final online publication date for the Annual Review of Biochemistry, Volume 90 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.Keywords
This publication has 155 references indexed in Scilit:
- Inverted genomic segments and complex triplication rearrangements are mediated by inverted repeats in the human genomeNature Genetics, 2011
- Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic RearrangementsCell, 2011
- The genomic complexity of primary human prostate cancerNature, 2011
- Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer DevelopmentCell, 2011
- Recruitment to stalled replication forks of the PriA DNA helicase and replisome-loading activities is essential for survivalDNA Repair, 2010
- Mechanisms of change in gene copy numberNature Reviews Genetics, 2009
- Flexibility of Eukaryotic Okazaki Fragment Maturation through Regulated Strand Displacement SynthesisOnline Journal of Public Health Informatics, 2008
- Large inverted repeats in the vicinity of a single double-strand break strongly affect repair in yeast diploids lacking Rad51Mutation research. Reviews in mutation research, 2008
- DNA polymerase θ (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproductDNA Repair, 2008
- Double‐strand breaks arising by replication through a nick are repaired by cohesin‐dependent sister‐chromatid exchangeEMBO Reports, 2006