Wolbachia strain wAu efficiently blocks arbovirus transmission in Aedes albopictus
Open Access
- 29 February 2020
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLoS Neglected Tropical Diseases
- Vol. 14 (3), e0007926
- https://doi.org/10.1371/journal.pntd.0007926
Abstract
The global incidence of arboviral diseases transmitted by Aedes mosquitoes, including dengue, chikungunya, yellow fever, and Zika, has increased dramatically in recent decades. The release of Aedes aegypti carrying the maternally inherited symbiont Wolbachia as an intervention to control arboviruses is being trialled in several countries. However, these efforts are compromised in many endemic regions due to the co-localization of the secondary vector Aedes albopictus, the Asian tiger mosquito. Ae. albopictus has an expanding global distribution following incursions into a number of new territories. To date, only the wMel and wPip strains of Wolbachia have been reported to be transferred into and characterized in this vector. A Wolbachia strain naturally infecting Drosophila simulans, wAu, was selected for transfer into a Malaysian Ae. albopictus line to create a novel triple-strain infection. The newly generated line showed self-compatibility, moderate fitness cost and complete resistance to Zika and dengue infections. Author summary Aedes albopictus, the invasive Asian tiger mosquito, is responsible for numerous outbreaks of important viruses such as dengue and Zika in various regions of the world. The need for alterative control interventions propelled the development of a novel approach that exploits a natural insect symbiont, Wolbachia; when transferred into non-native hosts, these maternally-inherited bacteria are able to interfere with the transmission of mosquito-borne viruses, and also provide reproductive advantages to the host, offering a promising tool for self-sustaining field applications. Currently, several field trials are ongoing for the primary vector of dengue and several other arboviruses, Aedes aegypti, providing encouraging results. In this study, Ae. albopictus has been targeted for a similar approach: this mosquito species naturally carries two strains of Wolbachia. The introduction of a third, non-native strain made this line less able to transmit dengue and Zika viruses and had an impact on its fitness.Funding Information
- Wellcome Trust (108508/Z/15/Z)
- Wellcome Trust (202888/Z/16/Z)
This publication has 51 references indexed in Scilit:
- Rapid Sequential Spread of Two Wolbachia Variants in Drosophila simulansPLoS Pathogens, 2013
- A Wolbachia wMel Transinfection in Aedes albopictus Is Not Detrimental to Host Fitness and Inhibits Chikungunya VirusPLoS Neglected Tropical Diseases, 2013
- Antiviral Protection and the Importance of Wolbachia Density and Tissue Tropism in Drosophila simulansApplied and Environmental Microbiology, 2012
- Wolbachia Induces Density-Dependent Inhibition to Dengue Virus in Mosquito CellsPLoS Neglected Tropical Diseases, 2012
- WolbachiastrainwMel induces cytoplasmic incompatibility and blocks dengue transmission inAedes albopictusProceedings of the National Academy of Sciences of the United States of America, 2011
- The Chikungunya Epidemic on La Réunion Island in 2005–2006: A Cost-of-Illness StudyPLoS Neglected Tropical Diseases, 2011
- The Endosymbiotic Bacterium Wolbachia Induces Resistance to Dengue Virus in Aedes aegyptiPLoS Pathogens, 2010
- Pathogenicity of Life-Shortening Wolbachia in Aedes albopictus after Transfer from Drosophila melanogasterApplied and Environmental Microbiology, 2009
- The Bacterial Symbiont Wolbachia Induces Resistance to RNA Viral Infections in Drosophila melanogasterPLoS Biology, 2008
- Spread of The Tiger: Global Risk of Invasion by The MosquitoAedes albopictusVector-Borne and Zoonotic Diseases, 2007