Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer
- 14 June 2021
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Medicine
- Vol. 11 (11), a037838
- https://doi.org/10.1101/cshperspect.a037838
Abstract
Lung cancer is a heterogeneous disease that is subdivided into histopathological subtypes with distinct behaviors. Each subtype is characterized by distinct features and molecular alterations that influence tumor metabolism. Alterations in tumor metabolism can be exploited by imaging modalities that use metabolite tracers for the detection and characterization of tumors. Microenvironmental factors, including nutrient and oxygen availability and the presence of stromal cells, are a critical influence on tumor metabolism. Recent technological advances facilitate the direct evaluation of metabolic alterations in patient tumors in this complex microenvironment. In addition, molecular alterations directly influence tumor cell metabolism and metabolic dependencies that influence response to therapy. Current therapeutic approaches to target tumor metabolism are currently being developed and translated into the clinic for patient therapy.This publication has 203 references indexed in Scilit:
- Metabolic Regulation by p53 Family MembersCell Metabolism, 2013
- Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesisJCI Insight, 2013
- LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug PhenforminCancer Cell, 2013
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1Cell, 2012
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEBThe EMBO Journal, 2012
- The AMPK signalling pathway coordinates cell growth, autophagy and metabolismNature, 2011
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1Molecular Cell, 2010
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino AcidsCell, 2010
- HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancerNature, 2009
- An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor ReceptorCell, 2006