Changes in the epidemiology and management of bacterial infections in cirrhosis
Open Access
- 1 July 2021
- journal article
- review article
- Published by The Korean Association for the Study of the Liver in Clinical and Molecular Hepatology
- Vol. 27 (3), 437-445
- https://doi.org/10.3350/cmh.2020.0329
Abstract
Patients with cirrhosis are susceptible to develop infections because of immune dysfunction, changes in microbiome and increase in bacterial translocation from the gut to systemic circulation. Bacterial infections can worse the clinical course of the disease, triggering the development of complications such as acute kidney injury, hepatic encephalopathy, organ failures and acute on chronic liver failure. In recent years, the spread of multi drug resistant bacteria made more challenging the management of infections in patients with cirrhosis. Hence, the mortality rate associated to sepsis is increasing in these patients. Therefore, the optimization of the management of infections has a high priority in cirrhosis. Herein we reviewed the recent changes in the epidemiology and the management of bacterial infections in patients with liver cirrhosis.Keywords
Funding Information
- EU Horizon 2020 programme (H2020-SC1-2016-RTD)
- LIVERHOPE (731875)
This publication has 63 references indexed in Scilit:
- Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled studyJournal of Hepatology, 2012
- Antimicrobial therapeutic determinants of outcomes from septic shock among patients with cirrhosisJournal of Hepatology, 2012
- Low-dose hydrocortisone in patients with cirrhosis and septic shock: a randomized controlled trialCMAJ : Canadian Medical Association Journal, 2010
- β‐Blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: a meta‐analysisLiver International, 2009
- Clinical Significance and Outcome of Nosocomial Acquisition of Spontaneous Bacterial Peritonitis in Patients with Liver CirrhosisClinical Infectious Diseases, 2009
- Renal failure and bacterial infections in patients with cirrhosis: Epidemiology and clinical featuresJournal of Hepatology, 2006
- Norfloxacin vs Ceftriaxone in the Prophylaxis of Infections in Patients With Advanced Cirrhosis and HemorrhageGastroenterology, 2006
- Adrenal insufficiency in patients with cirrhosis and septic shock: Effect of treatment with hydrocortisone on survivalJournal of Hepatology, 2006
- Bacterial infections in cirrhosis: Epidemiological changes with invasive procedures and norfloxacin prophylaxisJournal of Hepatology, 2002
- Norfloxacin prevents spontaneous bacterial peritonitis recurrence in cirrhosis: Results of a double-blind, placebo-controlled trialJournal of Hepatology, 1990