Reconsidering the Role of Melatonin in Rheumatoid Arthritis
Open Access
- 20 April 2020
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 21 (8), 2877
- https://doi.org/10.3390/ijms21082877
Abstract
Rheumatoid arthritis (RA) is an inflammatory joint disorder characterized by synovial proliferation and inflammation, with eventual joint destruction if inadequately treated. Modern therapies approved for RA target the proinflammatory cytokines or Janus kinases that mediate the initiation and progression of the disease. However, these agents fail to benefit all patients with RA, and many lose therapeutic responsiveness over time. More effective or adjuvant treatments are needed. Melatonin has shown beneficial activity in several animal models and clinical trials of inflammatory autoimmune diseases, but the role of melatonin is controversial in RA. Some research suggests that melatonin enhances proinflammatory activities and thus promotes disease activity in RA, while other work has documented substantial anti-inflammatory and immunoregulatory properties of melatonin in preclinical models of arthritis. In addition, disturbance of the circadian rhythm is associated with RA development and melatonin has been found to affect clock gene expression in joints of RA. This review summarizes current understanding about the immunopathogenic characteristics of melatonin in RA disease. Comprehensive consideration is required by clinical rheumatologists to balance the contradictory effects.Funding Information
- National Science Council (MOST108-2320-B-039-065, MOST 108-2320-B-039-064-)
- China Medical University Hospital (DMR-109-208)
- China Medical University, Taiwan (CMU108-MF-14)
This publication has 56 references indexed in Scilit:
- Modulation by Melatonin of the Pathogenesis of Inflammatory Autoimmune DiseasesInternational Journal of Molecular Sciences, 2013
- Circadian Timekeeping Is Disturbed in Rheumatoid Arthritis at Molecular LevelPLOS ONE, 2013
- The Pathogenesis of Rheumatoid ArthritisThe New England Journal of Medicine, 2011
- Melatonin as an adjuvant therapy in patients with rheumatoid arthritisBritish Journal of Clinical Pharmacology, 2008
- Melatonin treatment does not improve rheumatoid arthritisBritish Journal of Clinical Pharmacology, 2008
- Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatoninBritish Journal of Clinical Pharmacology, 2007
- The role of melatonin in immuno‐enhancement: potential application in cancerInternational Journal of Experimental Pathology, 2006
- Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean populationJournal of Pineal Research, 2005
- Protective Effect of Melatonin on Zymosan-Induced Cellular DamageNeurosignals, 1999
- The melatonin rhythm: both a clock and a calendarCellular and Molecular Life Sciences, 1993