A Follicle-Stimulating Hormone Exacerbates the Progression of Periapical Inflammation Through Modulating the Cytokine Release in Periodontal Tissue
- 1 August 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Inflammation
- Vol. 43 (4), 1572-1585
- https://doi.org/10.1007/s10753-020-01234-9
Abstract
Menopause is directly related to a systemically low grade of inflammation, indicating that postmenopausal women might be more prone to the development of inflammation. The high levels of circulating follicle-stimulating hormone (FSH) may cause hypogonadal bone loss during postmenopausal osteoporosis independent of estrogen. Previous research revealed that FSH could aggravate alveolar bone loss during experimental periapical lesions in ovariectomized rats; however, the mechanisms for these effects remain unclear. In this study, we showed that FSH enhanced the expression and secretion of the proinflammatory cytokines interleukin (IL)-1 beta, IL-6, and tumor necrosis factor alpha to a significant degree in human periodontal ligament (hPDL) cells. Furthermore, FSH upregulatedPorphyromonas gingivalislipopolysaccharide (pgLPS)-induced proinflammatory cytokine production. Furthermore,in vivostudies demonstrated that FSH increased the levels of the aforementioned cytokines in the serum and enhanced the expression of Toll-like receptor 4 at both the messenger RNA and protein levels in hPDL cells and periodontal tissues. Our research suggests that high FSH levels may regulate the immune status of periodontal tissues during the postmenopausal period and, to a certain extent, suggested that postmenopausal women might be more prone to the development of inflammation of the periapical periodontitis and more obvious bone loss.Funding Information
- National Natural Science Foundation of China (81700772, 81700965)
- Youth Scientific Research Funds of the School of Stomatology, Shandong University (2018QNJJ05)
This publication has 31 references indexed in Scilit:
- Blocking antibody to the β-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesisProceedings of the National Academy of Sciences of the United States of America, 2012
- The human periodontal ligament cell: a fibroblast-like cell acting as an immune cellJournal of Periodontal Research, 2010
- Follicle-stimulating hormone, interleukin-1, and bone density in adult womenAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2010
- FSH Aggravates Periodontitis-related Bone Loss in Ovariectomized RatsJournal of Dental Research, 2010
- Menopause and Ovariectomy Cause a Low Grade of Systemic Inflammation that May Be Prevented by Chronic Treatment with Low Doses of Estrogen or LosartanThe Journal of Immunology, 2009
- The role of Toll‐like receptors 2 and 4 on reactive oxygen species and nitric oxide production by macrophage cells stimulated with root canal pathogensOral Microbiology and Immunology, 2008
- Newly reported roles of thyroid-stimulating hormone and follicle-stimulating hormone in bone remodellingInternational Orthopaedics, 2007
- Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formationProceedings of the National Academy of Sciences of the United States of America, 2006
- Estrogen deficiency and bone loss: an inflammatory taleJCI Insight, 2006
- A Comparative Study of Human Periodontal Ligament Cells and Gingival Fibroblasts in vitroJournal of Dental Research, 1988