Upstream and downstream of mTOR
Top Cited Papers
Open Access
- 15 August 2004
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 18 (16), 1926-1945
- https://doi.org/10.1101/gad.1212704
Abstract
The kinase mTOR integrates signals triggered by energy, stress, oxygen levels and growth factors. It regulates ribosome biogenesis, mRNA translation, nutrient metabolism, and autophagy. mTOR participates in various functions of the brain, such as synaptic plasticity, adult neurogenesis, memory and learning. mTOR is present during early neural development and participates in axon and dendrite development, neuron differentiation, and gliogenesis, among other processes. Furthermore, mTOR has been shown to modulate lifespan in multiple organisms. This protein is an important energy sensor that is present throughout our lifespan; its role must be precisely described in order to develop therapeutic strategies and prevent diseases of the central nervous system. The aim of this review is to present our current understanding of the functions of mTOR in neural development, the adult brain and aging.Keywords
This publication has 204 references indexed in Scilit:
- The progesterone-induced enhancement of object recognition memory consolidation involves activation of the extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR) pathways in the dorsal hippocampusHormones and Behavior, 2012
- TOR on the brainExperimental Gerontology, 2011
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogasterCell Metabolism, 2010
- DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212Neuron, 2009
- Autophagy and aging: keeping that old broom workingTrends in Genetics, 2008
- Influence of TOR kinase on lifespan in C. elegansNature, 2003
- mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth MachineryCell, 2002
- HEAT repeats in the Huntington's disease proteinNature Genetics, 1995
- Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progressionCell, 1993
- The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic miceNature, 1985