The recent progress on metal–organic frameworks for phototherapy
Top Cited Papers
- 26 February 2021
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 50 (8), 5086-5125
- https://doi.org/10.1039/d1cs00056j
Abstract
Some infectious or malignant diseases such as cancers are seriously threatening the health of human beings all over the world. The commonly used antibiotic therapy cannot effectively treat these diseases within a short time, and also bring about adverse effects such as drug resistance and immune system damage during long-term systemic treatment. Phototherapy is an emerging antibiotic-free strategy to treat these diseases. Upon light irradiation, phototherapeutic agents can generate cytotoxic reactive oxygen species (ROS) or induce a temperature increase, which leads to the death of targeted cells. These two kinds of killing strategies are referred to as photodynamic therapy (PDT) and photothermal therapy (PTT), respectively. So far, many photo-responsive agents have been developed. Among them, the metal–organic framework (MOF) is becoming one of the most promising photo-responsive materials because its structure and chemical compositions can be easily modulated to achieve specific functions. MOFs can have intrinsic photodynamic or photothermal ability under the rational design of MOF construction, or serve as the carrier of therapeutic agents, owing to its tunable porosity. MOFs also provide feasibility for various combined therapies and targeting methods, which improves the efficiency of phototherapy. In this review, we firstly investigated the principles of phototherapy, and comprehensively summarized recent advances of MOF in PDT, PTT and synergistic therapy, from construction to modification. We expect that our demonstration will shed light on the future development of this field, and bring it one step closer to clinical trials.Keywords
Funding Information
- National Natural Science Foundation of China (51871162, 51671081)
This publication has 329 references indexed in Scilit:
- Review of Long-Wavelength Optical and NIR Imaging Materials: Contrast Agents, Fluorophores, and Multifunctional Nano CarriersChemistry of Materials, 2012
- Magnetic nanomaterials for hyperthermia-based therapy and controlled drug deliveryAdvanced Drug Delivery Reviews, 2011
- Photodynamic therapy of cancer: An updateCA: A Cancer Journal for Clinicians, 2011
- Facile preparation and upconversion luminescence of graphene quantum dotsChemical Communications, 2010
- Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and OptimizationChemical Reviews, 2010
- Renal clearance of quantum dotsNature Biotechnology, 2007
- Plasmonic photothermal therapy (PPTT) using gold nanoparticlesLasers in Medical Science, 2007
- Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold NanorodsJournal of the American Chemical Society, 2006
- Photodynamic therapy: a new antimicrobial approach to infectious disease?Photochemical & Photobiological Sciences, 2004
- Photodynamic therapy for cancerNature Reviews Cancer, 2003