ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin
Open Access
- 23 February 2021
- journal article
- research article
- Published by American Society for Microbiology in mBio
- Vol. 12 (1)
- https://doi.org/10.1128/mbio.02705-20
Abstract
Apramycin is an aminoglycoside antibiotic that has been traditionally used in veterinary medicine. Recently, it has become an attractive candidate to repurpose in the fight against multidrug-resistant pathogens prioritized by the World Health Organization.Keywords
Funding Information
- Ontario Research Fund
- HHS | National Institutes of Health (HHSN272201700060C)
- HHS | NIH | National Institute of Allergy and Infectious Diseases (HHSN272201700060C)
- U.S. Department of Health and Human Services (HHSN272201700060C)
- Canada Research Chairs
- Gouvernement du Canada | Canadian Institutes of Health Research (FRN-148463)
This publication has 71 references indexed in Scilit:
- Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycinProceedings of the National Academy of Sciences of the United States of America, 2012
- The structural basis for substrate versatility of chloramphenicol acetyltransferase CATIProtein Science, 2012
- T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extensionNucleic Acids Research, 2011
- Aminoglycoside modifying enzymesDrug Resistance Updates, 2010
- Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteriaNucleic Acids Research, 2010
- Structural and Functional Studies of QdtC: An N-Acetyltransferase Required for the Biosynthesis of dTDP-3-Acetamido-3,6-dideoxy-α-d-glucoseBiochemistry, 2009
- Jalview Version 2—a multiple sequence alignment editor and analysis workbenchBioinformatics, 2009
- Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicityProceedings of the National Academy of Sciences of the United States of America, 2008
- Expresso: automatic incorporation of structural information in multiple sequence alignments using 3D-CoffeeNucleic Acids Research, 2006
- T-coffee: a novel method for fast and accurate multiple sequence alignmentJournal of Molecular Biology, 2000