Is there any role for surgery in the multidisciplinary treatment of esophageal cancer?
Open Access
- 1 October 2010
- journal article
- research article
- Published by Elsevier BV in Annals of Oncology
- Vol. 21 (suppl_7), vii283-vii285
- https://doi.org/10.1093/annonc/mdq294
Abstract
Due to the poor prognosis of patients after unimodal therapy like surgical resection or radiotherapy multidisciplinary treatment is regarded as standard of care in localized esophageal cancer. Within the last decade phase III trials investigating the curative potential of radiochemotherapy alone have challenged surgery to be an indispensible part of curative therapy. Nevertheless, surgical resection does play an important role in the multidisciplinary treatment. But its role is limited to subgroups of patients with a distinct clinical situation. Today it appears that particularly patients with adenocarcinomas of the lower esophagus and esophagogastric junction and those patients with squamous cell carcinomas not responding to induction chemo- or radiochemotherapy benefit from surgery. Patient selection according to their individual operative risk is most important to guide multidisciplinary therapy. Early molecular or diagnostic markers to predict response to chemo- or radiotherapy and also recurrence despite complete surgical resection are urgently needed.This publication has 17 references indexed in Scilit:
- Treatment of Esophageal Cancer Based on HistologyAmerican Journal of Clinical Oncology, 2009
- Predicting Systemic Disease in Patients With Esophageal Cancer After EsophagectomyAnnals of Surgery, 2008
- Phase III Trial of Trimodality Therapy With Cisplatin, Fluorouracil, Radiotherapy, and Surgery Compared With Surgery Alone for Esophageal Cancer: CALGB 9781Journal of Clinical Oncology, 2008
- Chemoradiation Followed by Surgery Compared With Chemoradiation Alone in Squamous Cancer of the Esophagus: FFCD 9102Journal of Clinical Oncology, 2007
- Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trialThe Lancet Oncology, 2005
- Chemoradiation With and Without Surgery in Patients With Locally Advanced Squamous Cell Carcinoma of the EsophagusJournal of Clinical Oncology, 2005
- Randomized Trial of Preoperative Chemoradiation Versus Surgery Alone in Patients With Locoregional Esophageal CarcinomaJournal of Clinical Oncology, 2001
- The evaluation and treatment of patients receiving radiation therapy for carcinoma of the esophagusCancer, 1999
- A Comparison of Multimodal Therapy and Surgery for Esophageal AdenocarcinomaThe New England Journal of Medicine, 1996
- Combined Chemotherapy and Radiotherapy Compared with Radiotherapy Alone in Patients with Cancer of the EsophagusThe New England Journal of Medicine, 1992