Antimicrobial resistance profile of extended- spectrum Beta-Lactamase producing Escherichia Coli at Ho Chi Minh City

Abstract

The antimicrobial resistance profile of extended-spectrumb -lactamase (ESBL) producing E. coli has been continuously changed in recent years in Vietnam and wordwide. A number of studies recently found that the prevalences of ESBL-producing E. coli decreased in Vietnam from 2016 to 2017 compared with those in previous years. The purpose of this study was to determine the prevalence and antimicrobial profile of ESBL-producing E. coli isolated from clinical specimens in Binh Dan hospital and from healthy individuals at Ho Chi Minh City in 2018. The results showed that the prevalence of ESBL-producing E. coli isolated from healthy individuals in 2018 and 2017 were nearly equal. The prevalence increased from 14.9% in 2017 up to 19.1% in 2018. The prevalence of ESBL-producing E. coli isolated from healthy individuals in Ho Chi Minh City was lower than that in other parts of Viet Nam. The prevalence of ESBL-producing E. coli isolated from clinical pecimens in Binh Dan hospital (22.25%) was lower than those in some other hospitals but higher compared with it from healthy individuals (19.1%). All of the ESBL-producing isolates were multidrug resistant and high resistance to aminoglycoside or quinolone. Imipenem and fosfomycin have still be considered as the treatment of choice against ESBL- producer infections. High resistance rate of E. coli isolated from blood specimens to imipenem was found in the study.