Bone microarchitectural alterations in boys with Duchenne muscular dystrophy on long-term glucocorticoid treatment
- 5 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Bone and Mineral Metabolism
- Vol. 39 (4), 606-611
- https://doi.org/10.1007/s00774-020-01196-w
Abstract
Introduction Osteoporosis is a major health issue in boys with Duchenne muscular dystrophy (DMD). Data on the specific bone deficits and microarchitectural alterations in children with DMD were limited. This study aimed to assess the bone microarchitectural alterations in boys with DMD on long-term glucocorticoid using high-resolution peripheral quantitative computed tomography (HR-pQCT). Materials and methods This was a cross-sectional, case–control study. Boys with DMD older than 5 years with no prior history of symptomatic fracture and had been on long-term glucocorticoid treatment were recruited from a single tertiary centre. For each participant, three gender- and age-matched controls were selected randomly from an existing HR-pQCT database of healthy individuals. Results Nine boys with DMD at a median age of 9.3 years were included. Three were found to have asymptomatic vertebral compression fracture. The HR-pQCT findings of these nine boys were compared with 27 healthy controls. Trabecular microstructure indices at the distal radius were significantly lower but the cortical vBMD was significantly higher in the DMD boys when compared with healthy controls. Conclusion Lower microarchitectural measurement of trabecular bones, but higher cortical vBMD, was observed in DMD boys on long-term oral glucocorticoid. The results from this study provide preliminary, yet important insights into the bone microarchitecture of this group of patients.Keywords
This publication has 18 references indexed in Scilit:
- Trabecular and Cortical Microstructure and Fragility of the Distal Radius in WomenJournal of Bone and Mineral Research, 2014
- Dual-Energy X-Ray Absorptiometry Interpretation and Reporting in Children and Adolescents: The Revised 2013 ISCD Pediatric Official PositionsJournal of Clinical Densitometry, 2014
- Fat Embolism Syndrome following minor trauma in Duchenne muscular dystrophyNeuromuscular Disorders, 2012
- Glucocorticoid effects on changes in bone mineral density and cortical structure in childhood nephrotic syndromeJournal of Bone and Mineral Research, 2012
- Revised Reference Curves for Bone Mineral Content and Areal Bone Mineral Density According to Age and Sex for Black and Non-Black Children: Results of the Bone Mineral Density in Childhood StudyJournal of Clinical Endocrinology & Metabolism, 2011
- Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial managementThe Lancet Neurology, 2010
- Divergent Effects of Glucocorticoids on Cortical and Trabecular Compartment BMD in Childhood Nephrotic SyndromeJournal of Bone and Mineral Research, 2009
- Deflazacort Use in Duchenne Muscular Dystrophy: An 8-Year Follow-UpPediatric Neurology, 2008
- Vertebral compression in Duchenne muscular dystrophy following deflazacortNeuromuscular Disorders, 2002
- Vertebral fracture assessment using a semiquantitative techniqueJournal of Bone and Mineral Research, 1993