Cervical carcinomas with a micropapillary component: a clinicopathological study of eight cases
- 14 December 2017
- journal article
- research article
- Published by Wiley in Histopathology
- Vol. 72 (4), 626-633
- https://doi.org/10.1111/his.13419
Abstract
Micropapillary carcinomas, or carcinomas with a micropapillary component, are well recognised in the breast and other anatomical sites. However, they have seldom been described in the cervix. In this article, we present a clinicopathological analysis of eight cervical tumours that showed at least a focal (≥5%) component of micropapillary carcinoma. The study group comprised eight cervical carcinomas (four adenocarcinomas and four adenosquamous carcinomas) with a micropapillary component. The median patient age was 41.5 years (range 27–65 years). At presentation, five patients were stage IB, two were stage IIB, and one was stage IV. The micropapillary component accounted for ≤25% of the tumour on initial biopsy or resection specimens in all but one case. Immunohistochemistry showed ‘inside-out’ (reverse polarity) mucin 1 staining along the cell membrane abutting the stroma. Four patients developed metastasis, all of whom showed a pure micropapillary pattern; this led to a misdiagnosis of an apparently independent peritoneal serous carcinoma in one case. All tumours showed diffuse p16 expression, and all three cases that were tested were positive for human papillomavirus (HPV) 18. Three of the six patients with at least 12 months of follow-up died of disease, and one is alive with distant metastasis. Usual-type (HPV-related) cervical carcinomas may show micropapillary differentiation, usually as a focal finding, and the cells show reverse polarity like similar tumours arising in other sites. Micropapillary cervical carcinoma appears to be a clinically aggressive malignancy, although this needs to be confirmed in larger studies.This publication has 35 references indexed in Scilit:
- Adenocarcinoma of uterine cervix with micropapillary pattern^|^mdash;A case report^|^mdash;The Journal of the Japanese Society of Clinical Cytology, 2013
- Advanced Papillary Serous Carcinoma of the Uterine Cervix: A Case with a Remarkable Response to Paclitaxel and Carboplatin Combination ChemotherapyRare Tumors, 2012
- Cervical adenocarcinoma presenting as a cardiac tamponade in a 57-year-old woman: a case reportJournal of Medical Case Reports, 2011
- Clinicopathological and molecular characterization of colorectal micropapillary carcinomaLaboratory Investigation, 2011
- Metastatic Carcinomas in the Cervix Mimicking Primary Cervical Adenocarcinoma and Adenocarcinoma In SituThe American Journal of Surgical Pathology, 2010
- Ovarian Low-grade and High-grade Serous CarcinomaAdvances in Anatomic Pathology, 2009
- Cervical adenocarcinoma metastatic to the ovary mimicking primary ovarian carcinomaPathology, 2009
- Micropapillary Lung AdenocarcinomaAmerican Journal of Clinical Pathology, 2009
- From Krukenberg to Today: The Ever Present Problems Posed by Metastatic Tumors in the Ovary. Part IIAdvances in Anatomic Pathology, 2007
- Invasive Micropapillary Carcinoma of the BreastAmerican Journal of Clinical Pathology, 2004