Multiple Levels of Immunological Memory and Their Association with Vaccination
Open Access
- 18 February 2021
- Vol. 9 (2), 174
- https://doi.org/10.3390/vaccines9020174
Abstract
Immunological memory is divided into many levels to counteract the provocations of diverse and ever-changing infections. Fast functions of effector memory and the superposition of both quantitatively and qualitatively plastic anticipatory memory responses together form the walls of protection against pathogens. Here we provide an overview of the role of different B and T cell subsets and their interplay, the parallel and independent functions of the B1, marginal zone B cells, T-independent- and T-dependent B cell responses, as well as functions of central and effector memory T cells, tissue-resident and follicular helper T cells in the memory responses. Age-related limitations in the immunological memory of these cell types in neonates and the elderly are also discussed. We review how certain aspects of immunological memory and the interactions of components can affect the efficacy of vaccines, in order to link our knowledge of immunological memory with the practical application of vaccination.Keywords
Funding Information
- European Union and the European Regional Development Fund (GINOP-2.3.2-15-2016-00050, VEKOP-2.1.1-15-2016-00098)
- National Research, Development and Innovation Office (K 125224)
This publication has 187 references indexed in Scilit:
- Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper CellsImmunity, 2011
- A human memory T cell subset with stem cell–like propertiesNature Medicine, 2011
- Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent ReporterCell, 2010
- PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cellsNature Immunology, 2010
- The function of follicular helper T cells is regulated by the strength of T cell antigen receptor bindingNature Immunology, 2009
- Safety and efficacy of neonatal vaccinationEuropean Journal of Immunology, 2009
- Aging murine B cells have decreased class switch induced by anti-CD40 or BAFFExperimental Gerontology, 2007
- In vivo imaging of germinal centres reveals a dynamic open structureNature, 2007
- B cell clones that sustain long-term plasmablast growth in T-independent extrafollicular antibody responsesProceedings of the National Academy of Sciences of the United States of America, 2006
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsNature, 1999