Physical and chemical enhancement of cancer cell death induced by cold atmospheric plasma
- 11 February 2021
- journal article
- review article
- Published by IOP Publishing in Japanese Journal of Applied Physics
- Vol. 60 (3), 030501
- https://doi.org/10.35848/1347-4065/abde55
Abstract
Cold atmospheric plasma (CAP) has gained increasing attention for its anticancer potential. CAP anticancer application is unique for its selective targeting of cancer cells than normal cells. These CAP effects are directly related to producing reactive oxygen species (ROS) and reactive nitrogen species in air and liquid environment. The ROS producing ability can vary greatly depending on the CAP source. CAP-induced an enormous amount of ROS in the liquid phase. However, incorporating extracellular ROS into the cells seems limited to the ROS in the liquid phase. It poses a crucial challenge to CAP clinical applications. This short review describes the potential strategies that allow the incorporation of CAP-induced ROS to enhance cancer cell death. Further, the possible combination of CAP with hyperthermia and redox modulating agent sulfasalazine (SSZ) is explained.Keywords
This publication has 57 references indexed in Scilit:
- Restoration of Sensitivity in Chemo — Resistant Glioma Cells by Cold Atmospheric PlasmaPLOS ONE, 2013
- Role of Glutathione in Cancer Progression and ChemoresistanceOxidative Medicine and Cellular Longevity, 2013
- Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemiaNature, 2012
- Plasmas meet nanoparticles—where synergies can advance the frontier of medicineJournal of Physics D: Applied Physics, 2011
- The x cystine/glutamate antiporter: A potential target for therapy of cancer and other diseasesJournal of Cellular Physiology, 2008
- Cellular responses to hyperthermia (40–46°C): Cell killing and molecular eventsInternational Journal of Hyperthermia, 2008
- Plasma Process. Polym. 9/2007Plasma Processes and Polymers, 2007
- Arc‐Free Atmospheric Pressure Cold Plasma Jets: A ReviewPlasma Processes and Polymers, 2007
- Non-thermal atmospheric pressure dischargesJournal of Physics D: Applied Physics, 2005
- The cellular and molecular basis of hyperthermiaCritical Reviews in Oncology/Hematology, 2002