All‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort
Open Access
- 19 December 2020
- journal article
- research article
- Published by Wiley in Journal of Diabetes Investigation
- Vol. 12 (8), 1425-1429
- https://doi.org/10.1111/jdi.13483
Abstract
We aimed to determine mortality risk in underweight patients with diabetic nephropathy for microalbuminuria or macroalbuminuria. We analyzed mortality and death‐cause data from BioBank Japan, with baseline years 2003–2007. We analyzed mortality rates from all causes and ischemic heart disease, according to body mass index (2). The mean (standard deviation) of patient age, body mass index, and glycated hemoglobin at enrollment was 61.6 years (11.7 years), 25.0 kg/m2 (4.4 kg/m2) and 7.7% (1.5%), respectively. Hazard ratios of all‐cause and ischemic heart disease mortality were highest (1.79 [P = 0.0001] and 2.95 [P = 0.027], respectively) in patients with body mass index 2, as compared with body mass index 22–24.9 kg/m2. All‐cause mortality risk for body mass index 2 was similar to that for current smokers (hazard ratio 1.70, P < 0.0001). Underweight could be a predictor of mortality risk in patients with diabetic nephropathy for microalbuminuria or macroalbuminuria.Keywords
This publication has 21 references indexed in Scilit:
- Dementia risk by combinations of metabolic diseases and body mass index: Japan Gerontological Evaluation Study Cohort StudyJournal of Diabetes Investigation, 2019
- Overview of the BioBank Japan Project: Study design and profileJournal of Epidemiology, 2017
- Overview of BioBank Japan follow-up data in 32 diseasesJournal of Epidemiology, 2017
- Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseasesJournal of Epidemiology, 2017
- Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan cohortJournal of Epidemiology, 2017
- Serum glucose, cholesterol and blood pressure levels in Japanese type 1 and 2 diabetic patients: BioBank JapanJournal of Epidemiology, 2017
- Evidence-based practice guideline for the treatment for diabetes in Japan 2013Diabetology International, 2015
- BMI and All‐cause Mortality Among Japanese Older Adults: Findings From the Japan Collaborative Cohort StudyObesity, 2010
- Relation of Low Body Mass to Death and Stroke in the Systolic Hypertension in the Elderly ProgramArchives of Internal Medicine, 2000
- Predictors of mortality in insulin dependent diabetes: 10 year observational follow up studyBMJ, 1996