Sex- and tissue-dependent creatine uptake in response to different creatine monohydrate doses in male and female Sprague–Dawley rats
- 25 June 2021
- journal article
- research article
- Published by Canadian Science Publishing in Applied Physiology, Nutrition, and Metabolism
- Vol. 46 (10), 1-5
- https://doi.org/10.1139/apnm-2021-0301
Abstract
Sprague–Dawley rats (n = 32) underwent 8-weeks of creatine monohydrate (CM) supplementation (0, 2.5, 5, and 10 g/L). Total creatine (TCr) concentrations in female white fibre-dominant gastrocnemius (WGAS) and cardiac muscle (HRT) were significantly higher compared with males (p < 0.05). CM supplementation increased TCr concentrations in female WGAS (p < 0.05) and HRT (p < 0.01) and in male red fibre-dominant gastrocnemius muscle (RGAS) (p < 0.05). Future research should further investigate sex-differences in basal levels of TCr and the response to CM supplementation. Novelty: There is a sex- and tissue-dependant response to CM supplementation in rats.Keywords
This publication has 10 references indexed in Scilit:
- Role of Creatine in the Heart: Health and DiseaseNutrients, 2021
- Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?Journal of the International Society of Sports Nutrition, 2021
- Creatine for women: a review of the relationship between creatine and the reproductive cycle and female-specific benefits of creatine therapyAmino Acids, 2016
- A simple practice guide for dose conversion between animals and humanJournal of Basic and Clinical Pharmacy, 2016
- Augmentation of Creatine in the HeartMini-Reviews in Medicinal Chemistry, 2015
- Creatine supplementation with specific view to exercise/sports performance: an updateJournal of the International Society of Sports Nutrition, 2012
- Sex and Gender Differences in Myocardial Hypertrophy and Heart FailureCirculation Journal, 2010
- Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal speciesLife Sciences, 2001
- Direct measurement of high-energy phosphate compounds in patients with neuromuscular diseaseMuscle & Nerve, 1999
- Muscle composition in relation to age and sexClinical Science, 1991