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TM6SF2 E167K Variant Overexpression Promotes Expression of Inflammatory Cytokines in the HCC Cell Line HEPA 1-6

Shuixian Du, Songling Liao, Shousheng Liu, Yongning Xin
Journal of Clinical and Translational Hepatology , Volume 7, pp 27-31; doi:10.14218/JCTH.2018.00055

Abstract: Background and Aims: Accumulated evidence has shown that chronic liver inflammation is one of the main risks of hepatocellular carcinoma (HCC), and E167K variant of the transmembrane 6 superfamily member 2 (TM6SF2) plays an important role in the progression of chronic liver diseases and HCC. The aim of this study was to explore effects of the TM6SF2 E167K variant on expression of the inflammatory cytokines TNF-α, IL-2, IL-6 and IL-8 in the HCC cell line HEPA 1-6.
Keywords: Hepatocellular carcinoma / inflammatory / Tm6sf2 / E167k Variant

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