HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness
Open Access
- 18 February 2021
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 81 (8), 2015-2028
- https://doi.org/10.1158/0008-5472.can-20-3044
Abstract
This study finds that HDAC11 suppresses LKB1 expression in HCC to promote cancer stemness, progression, and sorafenib resistance, suggesting the potential of targeting HDAC11 to treat HCC and overcome kinase inhibitor resistance.Keywords
Other Versions
Funding Information
- National Natural Science Foundation of China (81874040, 81873219, 81774180, 81560393)
- Guangxi Science (2016GXNSFFA380003)
- Natural Science Foundation of Guangxi (2015jjDA40010)
- Natural Science Foundation of Jiangsu Province (BK20181425)
- Young Elite Scientists Sponsorship Program by CACM (CACM-2018-QNRC2-B07)
- Shandong Key Research and Development Program (2018YFJH0505, 2019GSF108218, 2019GSF108139)
- Natural Science Foundation of Guangxi (ZR2020MH007)
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