Vitamin D and stress urinary incontinence in pregnancy: a cross‐sectional study
Open Access
- 1 June 2020
- journal article
- research article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 127 (13), 1704-1711
- https://doi.org/10.1111/1471-0528.16340
Abstract
Objective To assess the association between levels of vitamin D and urinary incontinence (UI) in pregnancy. Design A cross‐sectional study. Secondary analysis of a randomised controlled trial. Setting Two university hospitals in Norway. Population 851 healthy, pregnant women >18 years in gestational week 18‐22 with a singleton live fetus. Methods Data on UI were collected from a questionnaire at inclusion and serum analysis of 25‐hydroxy vitamin D (25(OH)D) was performed. Univariable and multivariable logistic regression analyses were applied to study associations between exposure and outcomes. Main Outcome Measures Prevalence of self‐reported UI, stress (SUI) and urge (UUI) or mixed UI. Results In total 230/851 (27%) of the participants were vitamin D insufficient (25(OH)D <50nmol/L) and 42% reported to have any UI. Women with 25(OH)D <50nmol/L were more likely to report any UI (p=0.03) and SUI (p<0.01) compared to women with 25(OH)D ≥50nmol/L. In a univariable logistic regression analysis, serum levels of 25(OH)D <50nmol/L was associated with increased risk of any UI (Odds Ratio, OR 1.5 with 95% Confidence interval CI (1.0, 2.1)), SUI only (OR 1.7 (1.2, 2.4)), but not mixed UI or UUI only (OR 0.8 (0.5,1.5)). In a multivariable logistic regression model, serum levels of 25(OH)D <50nmol/L was associated with a higher risk of experiencing SUI only (OR 1.5 (1.1,2.2)). Conclusions Serum 25(OH)D <50nmol/L was associated with increased risk of any UI and SUI in particular.This publication has 45 references indexed in Scilit:
- Determinants of vitamin D status in pregnant fair-skinned women in SwedenBritish Journal of Nutrition, 2013
- Vitamin D status in women with pelvic floor disorder symptomsInternational Urogynecology Journal, 2012
- The status of pelvic floor muscle training for womenCanadian Urological Association Journal, 2010
- Implications of vitamin D deficiency in pregnancy and lactationAmerican Journal of Obstetrics and Gynecology, 2010
- Vitamin D and Pelvic Floor Disorders in WomenObstetrics & Gynecology, 2010
- An international urogynecological association (IUGA)/international continence society (ICS) joint report on the terminology for female pelvic floor dysfunctionNeurourology and Urodynamics, 2009
- The effect of urinary incontinence status during pregnancy and delivery mode on incontinence postpartum. A cohort study*BJOG: An International Journal of Obstetrics and Gynaecology, 2009
- Prevalence of Symptomatic Pelvic Floor Disorders in US WomenJAMA, 2008
- Urinary Incontinence During PregnancyObstetrics & Gynecology, 2007
- Risk of Stress Urinary Incontinence Twelve Years After the First Pregnancy and DeliveryObstetrics & Gynecology, 2006