Double Trouble: Concomitant RB1 and BRCA2 Depletion Evokes Aggressive Phenotypes
Open Access
- 15 April 2020
- journal article
- editorial
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 26 (8), 1784-1786
- https://doi.org/10.1158/1078-0432.ccr-19-4033
Abstract
Coordinate single- or two copy loss of the BRCA2/RB1 tumor suppressor genes, which reside in close chromosomal proximity, were found to be associated with aggressive prostate cancer and therapeutic resistance. Modeling these events and analyses of human cancers suggest that dual depletion of BRCA2/RB1 may represent a distinct subtype of disease. See related article by Chakraborty et al., p. 2047Keywords
Funding Information
- NIH (5R01CA217329-03)
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