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The molecular mechanism of γ-aminobutyric acid against AD: the role of CEBPα/circAPLP2/miR-671-5p in regulating CNTN1/2 expression

Na Meng, Pengyu Pan, Shuang Hu, Chen Miao, Yixin Hu, Fangfang Wang, Jingzhu Zhang,
Published: 26 January 2023

Abstract: GABA was shown to have an antagonistic effect on AD by regulating CNTN1/2. Furthermore, circAPLP2 was found to be down-regulated in the AD brain, and the CEBPα/circAPLP2/miR-671-5p pathway mediates the regulation of CNTN1/2 expression by GABA.
Keywords: antagonistic / circAPLP2 / brain / acid against AD / mechanism of γ / γ aminobutyric acid

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