Amyotrophic Lateral Sclerosis

Abstract
The article by Brown et al. (July 13 issue)1 provides a comprehensive review of the mechanisms, pathophysiological processes, and clinical features of amyotrophic lateral sclerosis (ALS). However, although the options for disease-modifying treatment for ALS are limited, the importance of multidisciplinary symptom-based management, which may increase survival and improve quality of life, should be emphasized.2