Rationally Designed Transgene-Encoded Cell-Surface Polypeptide Tag for Multiplexed Programming of CAR T-cell Synthetic Outputs
Open Access
- 9 July 2021
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Immunology Research
- Vol. 9 (9), 1047-1060
- https://doi.org/10.1158/2326-6066.cir-20-0470
Abstract
The authors describe a cell-surface tag system that allows the generation of CAR T cells that recognize more than one target or carry the complex synthetic biology payloads needed to overcome current challenges to advancing CAR T-cell therapy.Other Versions
Funding Information
- St. Baldrick's Foundation
- Stand Up To Cancer Pediatric Dream Team Translational Research (SU2C-AACR-DT-27-17)
- Stand Up To Cancer
- Entertainment Industry Foundation
- American Association for Cancer Research
- Scientific Partner of SU2C
This publication has 40 references indexed in Scilit:
- Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T CellsClinical Cancer Research, 2013
- Engineering Human T Cells for Resistance to Methotrexate and Mycophenolate Mofetil as an In Vivo Cell Selection StrategyPLOS ONE, 2013
- A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cellsBlood, 2011
- Engraftment of human central memory-derived effector CD8+ T cells in immunodeficient miceBlood, 2011
- The B-cell tumor–associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptorBlood, 2010
- Antitransgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Redirected T Cells in HumansTransplantation and Cellular Therapy, 2010
- Enzymatic assembly of DNA molecules up to several hundred kilobasesNature Methods, 2009
- Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK–modified donor T cells after allogeneic hematopoietic cell transplantationBlood, 2006
- Structure of the extracellular region of HER2 alone and in complex with the Herceptin FabNature, 2003
- Human blymphocytes immortalization by epstein-barr virus in the presence of cyclosporin aIn Vitro Cellular & Developmental Biology, 1986