Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing
Top Cited Papers
Open Access
- 5 March 2021
- journal article
- research article
- Published by Wiley in Advanced Science
- Vol. 8 (8), 2003627
- https://doi.org/10.1002/advs.202003627
Abstract
Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21–51 kPa), large tensile strain (899–1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long‐lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long‐lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.Keywords
Funding Information
- National Natural Science Foundation of China (51925308, U1601206, 51872336, 51703254)
This publication has 59 references indexed in Scilit:
- Electricity and colloidal stability: How charge distribution in the tissue can affects wound healingMedical Hypotheses, 2014
- Positively charged nanofiltration (NF) membranes via UV grafting on sulfonated polyphenylenesulfone (sPPSU) for effective removal of textile dyes from wastewaterJournal of Membrane Science, 2012
- Nanoreinforced bacterial cellulose–montmorillonite composites for biomedical applicationsCarbohydrate Polymers, 2012
- Mussel-Inspired Adhesives and CoatingsAnnual Review of Materials Research, 2011
- Prevention of Surgical-Site InfectionsThe New England Journal of Medicine, 2010
- Grafting of Zwitterion from Cellulose Membranes via ATRP for Improving Blood CompatibilityBiomacromolecules, 2009
- Stimulation of neurite outgrowth using positively charged hydrogelsBiomaterials, 2009
- Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human CellsACS Nano, 2008
- The effect of hydrogel charge density on cell attachmentBiomaterials, 2004
- Fibroblast cell proliferation on charged hydroxyethyl methacrylate copolymersJournal of Colloid and Interface Science, 1985