Stress Responses as Master Keys to Epigenomic Changes in Transcriptome and Metabolome for Cancer Etiology and Therapeutics
- 1 January 2022
- journal article
- review article
- Published by Taylor & Francis Ltd in Molecular and Cellular Biology
- Vol. 42 (1), e0048321
- https://doi.org/10.1128/mcb.00483-21
Abstract
From initiation through progression, cancer cells are subjected to a magnitude of endogenous and exogenous stresses, which aid in their neoplastic transformation. Exposure to these classes of stress induces imbalance in cellular homeostasis and, in response, cancer cells employ informative adaptive mechanisms to rebalance biochemical processes that facilitate survival and maintain their existence. Different kinds of stress stimuli trigger epigenetic alterations in cancer cells, which leads to changes in their transcriptome and metabolome, ultimately resulting in suppression of growth inhibition or induction of apoptosis. Whether cancer cells show a protective response to stress or succumb to cell death depends on the type of stress and duration of exposure. A thorough understanding of epigenetic and molecular architecture of cancer cell stress response pathways can unveil a plethora of information required to develop novel anti-cancer therapeutics. The present view highlights current knowledge about alterations in epigenome and transcriptome of cancer cells as a consequence of exposure to different physicochemical stressful stimuli such as reactive oxygen species (ROS), hypoxia, radiation, hyperthermia, genotoxic agents, and nutrient deprivation. Currently, an anti-cancer treatment scenario involving the imposition of stress on target cancer cells is gaining traction to augment or even replace conventional therapeutic regimens. Therefore, a comprehensive understanding of stress response pathways is crucial for devising and implementing novel therapeutic strategies.Keywords
This publication has 235 references indexed in Scilit:
- Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG IslandsCancer Cell, 2011
- A review of the mammalian unfolded protein responseBiotechnology & Bioengineering, 2011
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1Cell, 2011
- SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIFCancer Cell, 2011
- Hyperthermia alters the interaction of proteins of the Mre11 complex in irradiated cellsCytometry Part A, 2010
- Nucleocytoplasmic shuttling of hexokinase II in a cancer cellBiochemical and Biophysical Research Communications, 2010
- Nuclear‐cytoplasmic localization of acetyl coenzyme a synthetase‐1 in the rat brainJournal of Comparative Neurology, 2010
- IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell FatesCell, 2009
- SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during HypoxiaCell, 2007
- Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of CarcinogenesisCell, 2007