The evolving blood donor deferral policy for men who have sex with men: impact on the risk of HIV transmission by transfusion in France
- 6 February 2020
- journal article
- research article
- Published by Wiley in Transfusion
- Vol. 60 (3), 525-534
- https://doi.org/10.1111/trf.15677
Abstract
BACKGROUND Blood donation deferral for men who have sex with men (MSM) in France was reduced from permanent to 12 months in July 2016. To inform a further reduction of the deferral period, an HIV risk assessment was conducted with two scenarios: S1, 4-month deferral; S2, 4-month deferral only in the case of more than one sexual partner (i.e., similar to other blood donors). METHODS Baseline HIV residual risk (RR) was calculated from July 2016 to December 2017, using the Incidence Rate-Window Period method. The impact of both scenarios on RR was assessed using data from surveys on MSM and blood donors, to estimate 1) the number of additional MSM expected to donate in each scenario and 2) HIV incidence among these donors. RESULTS Baseline HIV RR was estimated at 1 in 6,380,000 donations. For S1, an additional 733 MSM donors, and an additional 0.09 HIV-positive donations were estimated, yielding an unchanged RR of 1 in 6,300,000. For S2, these numbers were estimated at 3102 and 3.92, respectively, yielding an RR of 1 in 4,300,000. Sensitivity analyses showed that, under worst-case assumptions, the RR would equal 1 in 6,225,000 donations for S1 and 1 in 3,000,000 for S2. CONCLUSION For both scenarios, the HIV RR remains very low. For S1, the risk is identical to the baseline RR. For S2, it is 1.5 times higher, and sensitivity analysis shows that this estimate is less robust than for S1. The French Minister of Health announced that S1 will be implemented in April 2020.Keywords
This publication has 26 references indexed in Scilit:
- Estimating the Population Size of Men Who Have Sex with Men in the United States to Obtain HIV and Syphilis Rates§The Open AIDS Journal, 2012
- Donor Testing and Risk: Current Prevalence, Incidence, and Residual Risk of Transfusion-Transmissible Agents in US Allogeneic DonationsTransfusion Medicine Reviews, 2012
- A re‐evaluation of the risk of transfusion‐transmitted HIV prevented by the exclusion of men who have sex with men from blood donation in England and Wales, 2005–2007Vox Sanguinis, 2011
- Insights into the rise in HIV infections, 2001 to 2008: a Bayesian synthesis of prevalence evidenceAIDS, 2010
- The denominator problem: Estimating MSM-specific incidence of sexually transmitted infections and prevalence of HIV using population sizes of MSM derived from Internet surveysBMC Public Health, 2009
- Human immunodeficiency virus type 1 incidence among blood donors in France, 1992 through 2006: use of an immunoassay to identify recent infectionsTransfusion, 2008
- Development and Validation of an Immunoassay for Identification of Recent Human Immunodeficiency Virus Type 1 Infections and Its Use on Dried Serum SpotsJournal of Clinical Microbiology, 2005
- A new strategy for estimating risks of transfusion‐transmitted viral infections based on rates of detection of recently infected donorsTransfusion, 2005
- False‐negative testing errors in routine viral marker screening of blood donorsTransfusion, 2000
- The Risk of Transfusion-Transmitted Viral InfectionsThe New England Journal of Medicine, 1996