Background: The permanent incompetence to attain or preserve an erection is erectile dysfunction (ED). ED impacts a lot of men all over the world. Vasculogenic, hormonal, neurogenic, anatomical, drug-induced and psychogenic factors are included in ED pathophysiology. A significant pathophysiological factor underlying vasculogenic erectile dysfunction is endothelial dysfunction (EDys). Platelet Indices are significant biomarkers for platelet activation and pathophysiology of atherothrombsis, including average volume of platelets, width of platelet distribution and count of platelets. Measurement of Platelet indexes in diabetic males can detect erectile dysfunction early on. Objectives: The purpose of this research is to measure the PIs with ED in diabetic men and to associate among PIs and ED and also to associate among PIs and vasculogenic ED. Patients and Methods: The research was performed on 90 persons who were split into 3 groups: Group A: 30 diabetic male patients with ED, Group B: 30 diabetic male patients without ED, Group C: 30 healthy individuals as control. Results: A significant relationship among platelet indices, ED, and DM was shown in the present research. A statistically substantial increase was found in PIs (MPV, PDW) and HbA1C in ED with DM than DM and control groups. A statistically substantial decrease in PIs (PC) was also found in ED with DM than DM without and control groups. Conclusion: A substantial correlation in DM among platelet indices and ED. In patients with diabetes with ED, particularly those with vasculogenic pathology, PIs have increased.