Serum 25-Hydroxyvitamin D, Albumin, and Mortality Among Chinese Older Adults: A Population-based Longitudinal Study
- 5 June 2020
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 105 (8), 2762-2770
- https://doi.org/10.1210/clinem/dgaa349
Abstract
Context The associations between serum 25-hydroxyvitamin D concentrations [25(OH)D] and all-cause mortality have been inconsistent in existing literatures. One plausible reason is the interaction of intrinsic vitamin D with other biological conditions such as malnutrition and chronic inflammation. Objective To explore the associations between serum levels of 25(OH)D, albumin, and all-cause mortality and further evaluate their interactions in elderly people. Design Population-based longitudinal study. Setting and Participants Data were obtained from 1,834 people aged from 65 to 112 who had their serum 25(OH)D and albumin assayed at baseline in 2011. Participants’ survival status was ascertained at the 2014 and 2018 follow-up survey waves. Main Outcome Measures All-cause mortality. Results Among the 1,834 participants, both serum 25(OH)D and albumin concentrations were inversely associated with all-cause mortality (PsP=0.001). In the group with a higher albumin level (≥40 g/L), participants with a lower level of 25(OH)D (<50 nmol/L) had higher risk of mortality than their counterparts (Hazard ratio: 1.92, 95% Confidence Interval =1.45-2.56), and the association was more pronounced in women. In the group with a lower albumin level (<40 g/L), the associations failed to reach statistical significance in all participants as well as in women and in men. Conclusions Serum 25(OH)D and albumin levels were inversely associated with all-cause mortality in Chinese older adults. The association between 25(OH)D and mortality was more pronounced in participants with higher albumin levels.Keywords
Funding Information
- National Key Research and Development Program of China (2018YFC2000400)
- National Natural Sciences Foundation of China (71490732, 81903392, 81941021)
- China Postdoctoral Science Foundation (2019M650359)
This publication has 28 references indexed in Scilit:
- Vitamin D Levels and the Risk of Cognitive Decline in Chinese Elderly People: the Chinese Longitudinal Healthy Longevity SurveyThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2016
- Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United StatesBMJ, 2014
- C‐Reactive Protein, Vitamin D Deficiency, and Slow Gait SpeedJournal of the American Geriatrics Society, 2013
- Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Nonlinear AssociationJournal of Clinical Endocrinology & Metabolism, 2013
- Serum 25-hydroxyvitamin D levels and incident diabetes mellitus type 2: a competing risk analysis in a large population-based cohort of older adultsEuropean Journal of Epidemiology, 2013
- A Reverse J-Shaped Association of All-Cause Mortality with Serum 25-Hydroxyvitamin D in General Practice: The CopD StudyJournal of Clinical Endocrinology & Metabolism, 2012
- Vitamin D Deficiency, Inflammation, and Albuminuria in Chronic Kidney Disease: Complex InteractionsJournal of Renal Nutrition, 2011
- Plasma vitamin D and mortality in older men: a community-based prospective cohort studyThe American Journal of Clinical Nutrition, 2010
- Lower Levels of Serum Albumin and Total Cholesterol Associated with Decline in Activities of Daily Living and Excess Mortality in a 12‐Year Cohort Study of Elderly JapaneseJournal of the American Geriatrics Society, 2007
- Vitamin D Intake and Risk of Incident HypertensionHypertension, 2005