Endothelial Cell Migration on Poly(ε-caprolactone) Nanofibers Coated with a Nanohybrid Shish-Kebab Structure Mimicking Collagen Fibrils
- 1 March 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 21 (3), 1202-1213
- https://doi.org/10.1021/acs.biomac.9b01638
Abstract
Regulating cell migration dynamics is of significance in tissue engineering and regenerative medicine. A 3D scaffold was created to provide various topographies based on a poly(epsilon-caprolactone) (PCL) self-induced nanohybrid shish-kebab structure, which consisted of aligned PCL nanofibers and spaced PCL crystal lamellae grown on the fibers. Electrospinning was applied followed by self-induced crystallization. The results resembled natural collagen fibrils in an extracellular matrix. This variable microstructure enabled control of cell adhesion and migration. The kebab size was controlled by initial PCL concentrations. The geometry of cells seeded on the fibers was less elongated, but the adhesion was more polarized with a higher nuclear shape index and faster migration speed. These results could aid in rapid endothelialization in tissue engineering.Funding Information
- the ?111? Project of Henan Province and Technology development plan of Henan Science, the technology department (No. 162102210159, 172102210489)
- the Key Science & Technology Project for Institutions of Higher Education of Henan Province (19A430003, 20B430019)
- The International Science & Technology Cooperation Program of China (2015DFA30550)
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