Povidone iodine for the treatment of adenoviral conjunctivitis
- 11 February 2021
- journal article
- review article
- Published by Informa UK Limited in Clinical and Experimental Optometry
- Vol. 104 (3), 308-314
- https://doi.org/10.1080/08164622.2021.1877532
Abstract
Adenoviral conjunctivitis is the most common cause of ocular viral infection in the world, but currently has no approved therapeutic treatments. The antiseptic povidone-iodine (PVP-I) has been used as an off-label treatment for the condition, but high-quality evidence for its use is limited. This paper aims to review the literature surrounding the use of PVP-I in the management of adenoviral conjunctivitis. Unfortunately, treatment regimens, inclusion criteria, outcome measures, and review periods vary widely between studies, making direct comparisons between outcomes difficult. The majority of studies investigate daily instillation of 0.4 to 2.0% PVP-I rather than one-time instillation of PVP-I as has been used anecdotally in practice. In addition, only one treatment arm investigates daily PVP-I alone, with no significant difference in the duration of disease or clinical outcome compared to placebo. All other treatment arms investigate PVP-I in combination with dexamethasone which generally improve outcomes. Tolerability of PVP-I is generally good for low concentrations <1.0%, but efficacy of treatment is generally reported to be concentration dependent. Future research should investigate the optimal concentration, dosing regimen and role of each agent in combination treatment and aim to use laboratory techniques to improve diagnosis and provide quantifiable outcomes.Keywords
This publication has 47 references indexed in Scilit:
- Treatment of Epidemic Keratoconjunctivitis with 2% Povidone–Iodine: A Pilot StudyJournal of Ocular Pharmacology and Therapeutics, 2012
- Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activitiesVirology Journal, 2009
- Spread of Epidemic Keratoconjunctivitis Due to a Novel Serotype of Human Adenovirus in JapanJournal of Clinical Microbiology, 2009
- Iodine revisitedInternational Wound Journal, 2007
- Efficacy of Hospital Germicides against Adenovirus 8, a Common Cause of Epidemic Keratoconjunctivitis in Health Care FacilitiesAntimicrobial Agents and Chemotherapy, 2006
- Allergic contact dermatitis from povidone‐iodine: a re‐evaluation studyContact Dermatitis, 2005
- Sensitivity of human adenoviruses to different groups of chemical biocidesJournal of Hospital Infection, 2004
- Epidemic kerato-conjunctivitis—do outbreaks have to be epidemic?Eye, 2003
- Povidone-Iodine in Antisepsis – State of the ArtDermatology, 1997
- Inactivation of Human Viruses by Povidone-Iodine in Comparison with Other AntisepticsDermatology, 1997