Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction
Open Access
- 14 January 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cell and Developmental Biology
Abstract
Bone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic capability to regenerate upon injury, several pathologies and injuries could hamper the highly orchestrated bone formation and resorption process. Bone tissue engineering seeks to mimic the extracellular matrix of the tissue and the different biochemical pathways that lead to successful regeneration. For many years, the use of extrinsic factors (i.e., growth factors and drugs) to modulate these biological processes have been the preferred choice in the field. Even though it has been successful in some instances, this approach presents several drawbacks, such as safety-concerns, short release profile and half-time life of the compounds. On the other hand, the use of inorganic ions has attracted significant attention due to their therapeutic effects, stability and lower biological risks. Biomaterials play a key role in such strategies where they serve as a substrate for the incorporation and release of the ions. In this review, the methodologies used to incorporate ions in biomaterials is presented, highlighting the osteogenic properties of such ions and the roles of biomaterials in controlling their release.Keywords
Funding Information
- Ministerio de Ciencia e Innovación (RTI2018-096088-J-100, RYC2018-025977-I)
- Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya
This publication has 170 references indexed in Scilit:
- Silica-based mesoporous nanoparticles for controlled drug deliveryJournal of Tissue Engineering, 2013
- Surface modification of biomaterials using plasma immersion ion implantation and depositionInterface Focus, 2012
- Polymeric additives to enhance the functional properties of calcium phosphate cementsJournal of Tissue Engineering, 2012
- Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developmentsJournal of The Royal Society Interface, 2011
- The biology of fracture healingInjury, 2011
- Fgf-9 is required for angiogenesis and osteogenesis in long bone repairProceedings of the National Academy of Sciences of the United States of America, 2010
- NOTCHing the bone: Insights into multi-functionalityBone, 2010
- Role of matrix vesicles in biomineralizationBiochimica et Biophysica Acta (BBA) - General Subjects, 2009
- Effects of surface wettability and contact time on protein adhesion to biomaterial surfacesBiomaterials, 2007
- Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementCytotherapy, 2006